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OTUD4 deubiquitination stabilizes EGFR and activates the PI3K/AKT pathway to promote the invasiveness of triple-negative breast cancer.

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Title: OTUD4 deubiquitination stabilizes EGFR and activates the PI3K/AKT pathway to promote the invasiveness of triple-negative breast cancer.
Authors: Ren Y; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China., Zhou F; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.; Department of Breast Surgery, GuiYang Maternal and Child Health Care Hospital, Guiyang, China., Tan Z; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.; Department of Thyroid and Breast Sugery, Liupanshui Municipal People's Hospital, Liupanshui, China., Yang S; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China., Zhang S; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.; Department of General Surgery, Dejiang County People's Hospital, Tongren, China., Zhang Y; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China., Fu Y; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China., Zhang M; Department of Breast Surgery, Guiyang Second People's Hospital, Guiyang, China., Liu S; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. drliushu@163.com.; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China. drliushu@163.com.
Source: Cell death & disease [Cell Death Dis] 2026 Feb 23; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: OTUD4 deubiquitination stabilizes EGFR and activates the PI3K/AKT pathway to promote the invasiveness of triple-negative breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Ren+Y%22">Ren Y</searchLink>; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.<br /><searchLink fieldCode="AU" term="%22Zhou+F%22">Zhou F</searchLink>; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.; Department of Breast Surgery, GuiYang Maternal and Child Health Care Hospital, Guiyang, China.<br /><searchLink fieldCode="AU" term="%22Tan+Z%22">Tan Z</searchLink>; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.; Department of Thyroid and Breast Sugery, Liupanshui Municipal People's Hospital, Liupanshui, China.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.; Department of General Surgery, Dejiang County People's Hospital, Tongren, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Breast Surgery, Guiyang Second People's Hospital, Guiyang, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Breast Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. drliushu@163.com.; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China. drliushu@163.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41419-026-08482-x
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      – TitleFull: OTUD4 deubiquitination stabilizes EGFR and activates the PI3K/AKT pathway to promote the invasiveness of triple-negative breast cancer.
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              Text: 2026 Feb 23
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