View in EDS

A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients.

Saved in:
Bibliographic Details
Title: A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients.
Authors: Refardt J; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Potasso L; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; University Institute of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland., Pelouto A; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Trappe M; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Gregoriano C; Division of Endocrinology, Diabetes, and Metabolism and Division of General Internal Medicine, Medical University Clinic, Medical Faculty, University of Basel, Cantonal Hospital Aarau, Aarau, Switzerland., Koster M; Department of Endocrinology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Vodanovic ID; Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia., Norello D; Pituitary Diseases and Sodium Alterations Unit, Department of Endocrinology, Careggi University Hospital, Florence, Italy., Ravioli S; Department of Internal and Emergency Medicine, Public Hospital Solothurn, Solothurn, Switzerland.; Department of Emergency Medicine, Kepler University Hospital, Johannes Kepler University, Linz, Austria., Cukoski S; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Boesing M; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; University Institute of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland., Ryser B; Department of Internal and Emergency Medicine, Public Hospital Solothurn, Solothurn, Switzerland., Sambula L; Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia., Rapsch N; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Monnerat S; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Beck J; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Lustenberger S; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Vogt DR; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Werlen L; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., de Jesus JS; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Bontognali M; Department of Endocrinology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Schuetz P; Division of Endocrinology, Diabetes, and Metabolism and Division of General Internal Medicine, Medical University Clinic, Medical Faculty, University of Basel, Cantonal Hospital Aarau, Aarau, Switzerland., Zandbergen AAM; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Peri A; Pituitary Diseases and Sodium Alterations Unit, Department of Endocrinology, Careggi University Hospital, Florence, Italy.; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy., Kastelan D; Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia., Lindner G; Department of Internal and Emergency Medicine, Public Hospital Solothurn, Solothurn, Switzerland.; Department of Emergency Medicine, Kepler University Hospital, Johannes Kepler University, Linz, Austria., Leuppi J; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; University Institute of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland., Bilz S; Department of Endocrinology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland., Mueller B; Division of Endocrinology, Diabetes, and Metabolism and Division of General Internal Medicine, Medical University Clinic, Medical Faculty, University of Basel, Cantonal Hospital Aarau, Aarau, Switzerland., Burst V; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Hoorn EJ; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Christ-Crain M; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
Source: NEJM evidence [NEJM Evid] 2026 Mar; Vol. 5 (3), pp. EVIDoa2500086. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: NEJM Group, a division of the Massachusetts Medical Society Country of Publication: United States NLM ID: 9918317485806676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2766-5526 (Electronic) Linking ISSN: 27665526 NLM ISO Abbreviation: NEJM Evid Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41733398
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Refardt+J%22">Refardt J</searchLink>; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Potasso+L%22">Potasso L</searchLink>; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; University Institute of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pelouto+A%22">Pelouto A</searchLink>; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Trappe+M%22">Trappe M</searchLink>; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Gregoriano+C%22">Gregoriano C</searchLink>; Division of Endocrinology, Diabetes, and Metabolism and Division of General Internal Medicine, Medical University Clinic, Medical Faculty, University of Basel, Cantonal Hospital Aarau, Aarau, Switzerland.<br /><searchLink fieldCode="AU" term="%22Koster+M%22">Koster M</searchLink>; Department of Endocrinology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vodanovic+ID%22">Vodanovic ID</searchLink>; Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Norello+D%22">Norello D</searchLink>; Pituitary Diseases and Sodium Alterations Unit, Department of Endocrinology, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Ravioli+S%22">Ravioli S</searchLink>; Department of Internal and Emergency Medicine, Public Hospital Solothurn, Solothurn, Switzerland.; Department of Emergency Medicine, Kepler University Hospital, Johannes Kepler University, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Cukoski+S%22">Cukoski S</searchLink>; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Boesing+M%22">Boesing M</searchLink>; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; University Institute of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ryser+B%22">Ryser B</searchLink>; Department of Internal and Emergency Medicine, Public Hospital Solothurn, Solothurn, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sambula+L%22">Sambula L</searchLink>; Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Rapsch+N%22">Rapsch N</searchLink>; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Monnerat+S%22">Monnerat S</searchLink>; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Beck+J%22">Beck J</searchLink>; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lustenberger+S%22">Lustenberger S</searchLink>; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vogt+DR%22">Vogt DR</searchLink>; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Werlen+L%22">Werlen L</searchLink>; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22de+Jesus+JS%22">de Jesus JS</searchLink>; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bontognali+M%22">Bontognali M</searchLink>; Department of Endocrinology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schuetz+P%22">Schuetz P</searchLink>; Division of Endocrinology, Diabetes, and Metabolism and Division of General Internal Medicine, Medical University Clinic, Medical Faculty, University of Basel, Cantonal Hospital Aarau, Aarau, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zandbergen+AAM%22">Zandbergen AAM</searchLink>; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Peri+A%22">Peri A</searchLink>; Pituitary Diseases and Sodium Alterations Unit, Department of Endocrinology, Careggi University Hospital, Florence, Italy.; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Kastelan+D%22">Kastelan D</searchLink>; Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Lindner+G%22">Lindner G</searchLink>; Department of Internal and Emergency Medicine, Public Hospital Solothurn, Solothurn, Switzerland.; Department of Emergency Medicine, Kepler University Hospital, Johannes Kepler University, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Leuppi+J%22">Leuppi J</searchLink>; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.; University Institute of Internal Medicine, Cantonal Hospital Baselland, Liestal, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bilz+S%22">Bilz S</searchLink>; Department of Endocrinology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mueller+B%22">Mueller B</searchLink>; Division of Endocrinology, Diabetes, and Metabolism and Division of General Internal Medicine, Medical University Clinic, Medical Faculty, University of Basel, Cantonal Hospital Aarau, Aarau, Switzerland.<br /><searchLink fieldCode="AU" term="%22Burst+V%22">Burst V</searchLink>; Emergency Department, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hoorn+EJ%22">Hoorn EJ</searchLink>; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Christ-Crain+M%22">Christ-Crain M</searchLink>; Departments of Endocrinology, Diabetology, and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229918317485806676%22">NEJM evidence</searchLink> [NEJM Evid] 2026 Mar; Vol. 5 (3), pp. EVIDoa2500086. <i>Date of Electronic Publication: </i>2026 Feb 24.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Randomized Controlled Trial; Multicenter Study
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22NEJM+Group%2C+a+division+of+the+Massachusetts+Medical+Society%22">NEJM Group, a division of the Massachusetts Medical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918317485806676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2766-5526 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227665526%22">27665526 </searchLink><i>NLM ISO Abbreviation: </i>NEJM Evid <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41733398
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1056/EVIDoa2500086
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: EVIDoa2500086
    Titles:
      – TitleFull: A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Refardt J
      – PersonEntity:
          Name:
            NameFull: Potasso L
      – PersonEntity:
          Name:
            NameFull: Pelouto A
      – PersonEntity:
          Name:
            NameFull: Trappe M
      – PersonEntity:
          Name:
            NameFull: Gregoriano C
      – PersonEntity:
          Name:
            NameFull: Koster M
      – PersonEntity:
          Name:
            NameFull: Vodanovic ID
      – PersonEntity:
          Name:
            NameFull: Norello D
      – PersonEntity:
          Name:
            NameFull: Ravioli S
      – PersonEntity:
          Name:
            NameFull: Cukoski S
      – PersonEntity:
          Name:
            NameFull: Boesing M
      – PersonEntity:
          Name:
            NameFull: Ryser B
      – PersonEntity:
          Name:
            NameFull: Sambula L
      – PersonEntity:
          Name:
            NameFull: Rapsch N
      – PersonEntity:
          Name:
            NameFull: Monnerat S
      – PersonEntity:
          Name:
            NameFull: Beck J
      – PersonEntity:
          Name:
            NameFull: Lustenberger S
      – PersonEntity:
          Name:
            NameFull: Vogt DR
      – PersonEntity:
          Name:
            NameFull: Werlen L
      – PersonEntity:
          Name:
            NameFull: de Jesus JS
      – PersonEntity:
          Name:
            NameFull: Bontognali M
      – PersonEntity:
          Name:
            NameFull: Schuetz P
      – PersonEntity:
          Name:
            NameFull: Zandbergen AAM
      – PersonEntity:
          Name:
            NameFull: Peri A
      – PersonEntity:
          Name:
            NameFull: Kastelan D
      – PersonEntity:
          Name:
            NameFull: Lindner G
      – PersonEntity:
          Name:
            NameFull: Leuppi J
      – PersonEntity:
          Name:
            NameFull: Bilz S
      – PersonEntity:
          Name:
            NameFull: Mueller B
      – PersonEntity:
          Name:
            NameFull: Burst V
      – PersonEntity:
          Name:
            NameFull: Hoorn EJ
      – PersonEntity:
          Name:
            NameFull: Christ-Crain M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: 2026 Mar
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2766-5526
          Numbering:
            – Type: volume
              Value: 5
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: NEJM evidence
              Type: main
ResultId 1