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Antigen-boosted CD4CAR T cells fail to expand or control viremia in multiple nonhuman primate models of HIV.

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Title: Antigen-boosted CD4CAR T cells fail to expand or control viremia in multiple nonhuman primate models of HIV.
Authors: Maynard LH; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA.; Department of Bioengineering, University of Washington, Seattle, WA., Starke CE; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA., Poole NH; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA., Rust BJ; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA., Zhu H; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA., Stensland L; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA., Huang ML; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA., Pérez-Osorio AC; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA., Atherley JI; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA., Einhaus T; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA., Murray J; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA., Pampena MB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Jerome KR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA., Riley JL; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Kiem HP; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA.; Department of Medicine, University of Washington, Seattle, WA., Peterson CW; Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA.; Department of Medicine, University of Washington, Seattle, WA.
Source: Blood [Blood] 2026 May 28; Vol. 147 (22), pp. 2621-2632.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
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  Data: Antigen-boosted CD4CAR T cells fail to expand or control viremia in multiple nonhuman primate models of HIV.
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