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AI-driven pipeline discovers ombuin as a novel M1 macrophage polarization inhibitor for sepsis treatment.

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Title: AI-driven pipeline discovers ombuin as a novel M1 macrophage polarization inhibitor for sepsis treatment.
Authors: Gong SC; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China.; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Jiang L; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China., Li QX; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; ZJU-Xinchang Joint Innovation Center (TianMu Laboratory)), Xinchang, 312500, China., Yang C; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China., Yu L; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China., Lv SY; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China., Yang G; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China., Yang ZX; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China., Huang H; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China., Hu YM; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China., Chen XY; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China., Zhang HY; Institute of Intelligent Transportation Systems, College of Civil Engineering and Architecture, Zhejiang University, Hangzhou, 310007, China., Yang B; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; School of Medicine, Hangzhou City University, Hangzhou, 310015, China., He QJ; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; ZJU-Xinchang Joint Innovation Center (TianMu Laboratory)), Xinchang, 312500, China.; The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Department of Pharmaceutical and Translational Toxicology, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, 310058, China., Weng QJ; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China. wengqinjie@zju.edu.cn.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China. wengqinjie@zju.edu.cn.; The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. wengqinjie@zju.edu.cn.; Institute of Fundamental and Transdisciplinary Research Zhejiang University, Zhejiang University, Hangzhou, 310058, China. wengqinjie@zju.edu.cn., Wang JC; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China. wangjincheng@zju.edu.cn.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China. wangjincheng@zju.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jul; Vol. 47 (7), pp. 1900-1916. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: AI-driven pipeline discovers ombuin as a novel M1 macrophage polarization inhibitor for sepsis treatment.
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  Data: <searchLink fieldCode="AU" term="%22Gong+SC%22">Gong SC</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China.; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.<br /><searchLink fieldCode="AU" term="%22Li+QX%22">Li QX</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; ZJU-Xinchang Joint Innovation Center (TianMu Laboratory)), Xinchang, 312500, China.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China.<br /><searchLink fieldCode="AU" term="%22Lv+SY%22">Lv SY</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.<br /><searchLink fieldCode="AU" term="%22Yang+G%22">Yang G</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.<br /><searchLink fieldCode="AU" term="%22Yang+ZX%22">Yang ZX</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.<br /><searchLink fieldCode="AU" term="%22Hu+YM%22">Hu YM</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Chen+XY%22">Chen XY</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.<br /><searchLink fieldCode="AU" term="%22Zhang+HY%22">Zhang HY</searchLink>; Institute of Intelligent Transportation Systems, College of Civil Engineering and Architecture, Zhejiang University, Hangzhou, 310007, China.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; School of Medicine, Hangzhou City University, Hangzhou, 310015, China.<br /><searchLink fieldCode="AU" term="%22He+QJ%22">He QJ</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China.; ZJU-Xinchang Joint Innovation Center (TianMu Laboratory)), Xinchang, 312500, China.; The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Department of Pharmaceutical and Translational Toxicology, Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, 310058, China.<br /><searchLink fieldCode="AU" term="%22Weng+QJ%22">Weng QJ</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China. wengqinjie@zju.edu.cn.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China. wengqinjie@zju.edu.cn.; The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. wengqinjie@zju.edu.cn.; Institute of Fundamental and Transdisciplinary Research Zhejiang University, Zhejiang University, Hangzhou, 310058, China. wengqinjie@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+JC%22">Wang JC</searchLink>; Center for Drug Safety Evaluation and Research, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310007, China. wangjincheng@zju.edu.cn.; Taizhou Institute of Zhejiang University, Zhejiang University, Taizhou, 318000, China. wangjincheng@zju.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41401-026-01752-6
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      – Code: eng
        Text: English
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        StartPage: 1900
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              Text: 2026 Jul
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