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Blood PCSK9 Impacts Alzheimer's Disease Risk in an APOE Genotype-Dependent Manner: A Prospective Cohort Study.

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Title: Blood PCSK9 Impacts Alzheimer's Disease Risk in an APOE Genotype-Dependent Manner: A Prospective Cohort Study.
Authors: Tao Q; Department of Pharmacology, Physiology & Biophysics Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Anatomy & Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA., Ang TFA; Department of Anatomy & Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Slone Epidemiology Center, School of Public Health Boston University Medical Campus (BUMC) Boston Massachusetts USA.; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA., Huang J; Department of Pharmacology, Physiology & Biophysics Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA., Itchapurapu IS; Department of Pharmacology, Physiology & Biophysics Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA., Mez J; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA., Alosco M; Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA., Au R; Department of Anatomy & Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Slone Epidemiology Center, School of Public Health Boston University Medical Campus (BUMC) Boston Massachusetts USA.; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA., Farrer LA; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Medicine Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA., Zhang X; Department of Medicine Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA., Qiu WQ; Department of Pharmacology, Physiology & Biophysics Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Psychiatry Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.
Corporate Authors: Alzheimer's Disease Neuroimaging Initiative
Source: Health science reports [Health Sci Rep] 2026 Feb 22; Vol. 9 (2), pp. e71810. Date of Electronic Publication: 2026 Feb 22 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 101728855 Publication Model: eCollection Cited Medium: Internet ISSN: 2398-8835 (Electronic) Linking ISSN: 23988835 NLM ISO Abbreviation: Health Sci Rep Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Blood PCSK9 Impacts Alzheimer's Disease Risk in an APOE Genotype-Dependent Manner: A Prospective Cohort Study.
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  Data: <searchLink fieldCode="AU" term="%22Tao+Q%22">Tao Q</searchLink>; Department of Pharmacology, Physiology & Biophysics Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Anatomy & Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Ang+TFA%22">Ang TFA</searchLink>; Department of Anatomy & Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Slone Epidemiology Center, School of Public Health Boston University Medical Campus (BUMC) Boston Massachusetts USA.; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Pharmacology, Physiology & Biophysics Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Itchapurapu+IS%22">Itchapurapu IS</searchLink>; Department of Pharmacology, Physiology & Biophysics Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Mez+J%22">Mez J</searchLink>; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Alosco+M%22">Alosco M</searchLink>; Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Au+R%22">Au R</searchLink>; Department of Anatomy & Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Slone Epidemiology Center, School of Public Health Boston University Medical Campus (BUMC) Boston Massachusetts USA.; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Farrer+LA%22">Farrer LA</searchLink>; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Medicine Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Medicine Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.<br /><searchLink fieldCode="AU" term="%22Qiu+WQ%22">Qiu WQ</searchLink>; Department of Pharmacology, Physiology & Biophysics Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.; Department of Psychiatry Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA.
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