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Spatial transcriptomics uncovers hybrid, proinflammatory, and profibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis.

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Title: Spatial transcriptomics uncovers hybrid, proinflammatory, and profibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis.
Authors: Christian L; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Yilmaz H; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Ruwisch J; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Giercke L; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Seeliger B; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Kamp JC; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Bayraktar S; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany., Ewen R; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Graalmann T; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Junior Research Group Translational Immunology, TWINCORE, Center for Experimental and Clinical Infection Research, a Joint Venture between the Helmholtz Center for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Department for Rheumatology and Immunology, Hannover Medical School (MHH), Hannover, Germany., Fuge J; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Greer M; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Ius F; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Clinic for Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School (MHH), Hannover, Germany., Welte T; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Liao SY; Department of Medicine, National Jewish Health, Denver, CO, United States., Yang IV; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, United States., Hohlfeld JM; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Division of Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany., Hoeper MM; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Gottlieb J; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany., Kaminski N; Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT, United States., Prasse A; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Division of Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.; Clinics of Respiratory Medicine, University Hospital Basel, University of Basel, Basel, Switzerland., Jonigk D; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany.; University Clinic of the RWTH Aachen, Aachen, Germany., Li Y; Computational Biology for Individualised Medicine, TWINCORE, Center for Experimental and Clinical Infection Research, a Joint Venture between the Helmholtz Center for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Department of Computational Biology for Individualised Medicine, Center for Individualised Infection Medicine (CiiM), a Joint Venture between the Helmholtz Center for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Lower Saxony Center for Artificial Intelligence and Causal Methods in Medicine (CAIMed), Hannover, Germany.; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.; Cluster of Excellence Resolving Infection Susceptibility (RESIST), Hannover, Germany., Falk C; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany., Neubert L; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany., Schupp JC; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Division of Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.; Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT, United States.
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Feb 01; Vol. 212 (2), pp. 338-350.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Spatial transcriptomics uncovers hybrid, proinflammatory, and profibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis.
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  Data: <searchLink fieldCode="AU" term="%22Christian+L%22">Christian L</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Yilmaz+H%22">Yilmaz H</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Ruwisch+J%22">Ruwisch J</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Giercke+L%22">Giercke L</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Seeliger+B%22">Seeliger B</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Kamp+JC%22">Kamp JC</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Bayraktar+S%22">Bayraktar S</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Ewen+R%22">Ewen R</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Graalmann+T%22">Graalmann T</searchLink>; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Junior Research Group Translational Immunology, TWINCORE, Center for Experimental and Clinical Infection Research, a Joint Venture between the Helmholtz Center for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Department for Rheumatology and Immunology, Hannover Medical School (MHH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Fuge+J%22">Fuge J</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Greer+M%22">Greer M</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Ius+F%22">Ius F</searchLink>; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Clinic for Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School (MHH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Welte+T%22">Welte T</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Liao+SY%22">Liao SY</searchLink>; Department of Medicine, National Jewish Health, Denver, CO, United States.<br /><searchLink fieldCode="AU" term="%22Yang+IV%22">Yang IV</searchLink>; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Hohlfeld+JM%22">Hohlfeld JM</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Division of Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hoeper+MM%22">Hoeper MM</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Gottlieb+J%22">Gottlieb J</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Kaminski+N%22">Kaminski N</searchLink>; Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT, United States.<br /><searchLink fieldCode="AU" term="%22Prasse+A%22">Prasse A</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Division of Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.; Clinics of Respiratory Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jonigk+D%22">Jonigk D</searchLink>; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany.; University Clinic of the RWTH Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Computational Biology for Individualised Medicine, TWINCORE, Center for Experimental and Clinical Infection Research, a Joint Venture between the Helmholtz Center for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Department of Computational Biology for Individualised Medicine, Center for Individualised Infection Medicine (CiiM), a Joint Venture between the Helmholtz Center for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.; Lower Saxony Center for Artificial Intelligence and Causal Methods in Medicine (CAIMed), Hannover, Germany.; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.; Cluster of Excellence Resolving Infection Susceptibility (RESIST), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Falk+C%22">Falk C</searchLink>; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Neubert+L%22">Neubert L</searchLink>; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Schupp+JC%22">Schupp JC</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), Hannover Medical School (MHH), German Center for Lung Research (DZL), Hannover, Germany.; Division of Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.; Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT, United States.
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