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The CFTR potentiator icenticaftor for treatment of bronchiectasis: an international phase 2, double-blind, randomized placebo-controlled trial.

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Title: The CFTR potentiator icenticaftor for treatment of bronchiectasis: an international phase 2, double-blind, randomized placebo-controlled trial.
Authors: Guan WJ; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China.; China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangdong Provincial Key Laboratory of Respiratory Disease Research, Guangzhou Medical University, Guangzhou, P. R. China., Haworth CS; Royal Papworth Hospital NHS Foundation Trust and Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Tiddens HAWM; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Thirona, Nijmegen, The Netherlands., Loebinger MR; Host Defence Unit, Royal Brompton Hospital, London, United Kingdom.; NHLI, Imperial College London, London, United Kingdom., Hill AT; Centre for Inflammation Research Institute for Regeneration and Repair, The University of Edinburgh Edinburgh BioQuarter, Edinburgh, United Kingdom., Sibila O; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias M.P. (CIBERES), Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Respiratory Department, Hospital Clínic, University of Barcelona, Barcelona, Spain., Ringshausen FC; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany.; European Reference Network on Rare and Complex Respiratory Diseases (ERN-LUNG), Frankfurt, Germany., Stuart BD; Biomedical Research, Novartis, Cambridge, MA, United States., Wang Y; Analytics-EDA, Novartis, Shanghai, China., Elborn JS; Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom., Zhong NS; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China.; China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangdong Provincial Key Laboratory of Respiratory Disease Research, Guangzhou Medical University, Guangzhou, P. R. China., Chalmers JD; Division of Respiratory Medicine and Gastroenterology, University of Dundee, Dundee, United Kingdom.; John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Jun 01; Vol. 212 (6), pp. 1343-1346.
Publication Type: Journal Article
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: The CFTR potentiator icenticaftor for treatment of bronchiectasis: an international phase 2, double-blind, randomized placebo-controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Guan+WJ%22">Guan WJ</searchLink>; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China.; China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangdong Provincial Key Laboratory of Respiratory Disease Research, Guangzhou Medical University, Guangzhou, P. R. China.<br /><searchLink fieldCode="AU" term="%22Haworth+CS%22">Haworth CS</searchLink>; Royal Papworth Hospital NHS Foundation Trust and Department of Medicine, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tiddens+HAWM%22">Tiddens HAWM</searchLink>; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Thirona, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Loebinger+MR%22">Loebinger MR</searchLink>; Host Defence Unit, Royal Brompton Hospital, London, United Kingdom.; NHLI, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hill+AT%22">Hill AT</searchLink>; Centre for Inflammation Research Institute for Regeneration and Repair, The University of Edinburgh Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sibila+O%22">Sibila O</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias M.P. (CIBERES), Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Respiratory Department, Hospital Clínic, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ringshausen+FC%22">Ringshausen FC</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School (MHH), Hannover, Germany.; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany.; European Reference Network on Rare and Complex Respiratory Diseases (ERN-LUNG), Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Stuart+BD%22">Stuart BD</searchLink>; Biomedical Research, Novartis, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Analytics-EDA, Novartis, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Elborn+JS%22">Elborn JS</searchLink>; Centre for Infection and Immunity, Queen's University Belfast, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zhong+NS%22">Zhong NS</searchLink>; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China.; China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangdong Provincial Key Laboratory of Respiratory Disease Research, Guangzhou Medical University, Guangzhou, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chalmers+JD%22">Chalmers JD</searchLink>; Division of Respiratory Medicine and Gastroenterology, University of Dundee, Dundee, United Kingdom.; John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Thoracic+Society%22">American Thoracic Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421642 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1535-4970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221073449X%22">1073449X </searchLink><i>NLM ISO Abbreviation: </i>Am J Respir Crit Care Med <i>Subsets: </i>MEDLINE; In Process
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              Text: 2026 Jun 01
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