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VSIG4 Restricts Hepatocellular Carcinoma Control by Suppressing Tumor-Specific CD8+ T-cell Immunity in the Tumor Microenvironment.

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Title: VSIG4 Restricts Hepatocellular Carcinoma Control by Suppressing Tumor-Specific CD8+ T-cell Immunity in the Tumor Microenvironment.
Authors: Guo J; Department of Cancer Immunology, Genentech, South San Francisco, California., Bhela S; Department of Cancer Immunology, Genentech, South San Francisco, California., Sharma M; Department of Research Biology, Genentech, South San Francisco, California., Protti G; Department of Computational Biology and Translation, Genentech, South San Francisco, California., Luoh SM; Department of Cancer Immunology, Genentech, South San Francisco, California., Wang S; Department of Cancer Immunology, Genentech, South San Francisco, California., Firmino NS; Department of Cancer Immunology, Genentech, South San Francisco, California., Dasoveanu DC; Department of Cancer Immunology, Genentech, South San Francisco, California., Chan C; Department of Research Pathology, Genentech, South San Francisco, California., Ibarra-Lopez V; Department of Research Pathology, Genentech, South San Francisco, California., Foo C; Department of Research Pathology, Genentech, South San Francisco, California., Jesudason R; Department of Research Pathology, Genentech, South San Francisco, California., Rost S; Department of Research Pathology, Genentech, South San Francisco, California., Scholl T; Department of Research Support Facility, Genentech, South San Francisco, California., Ziai J; Department of Research Pathology, Genentech, South San Francisco, California., Comps-Agrar L; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California., Wang Y; Department of Translational Medicine Oncology, Genentech, South San Francisco, California., Müller S; Department of Computational Biology and Translation, Genentech, South San Francisco, California., Shaw AS; Department of Research Biology, Genentech, South San Francisco, California., Li J; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California., Turley SJ; Department of Immunology and Regenerative Medicine, Genentech, South San Francisco, California., Fu W; Department of Cancer Immunology, Genentech, South San Francisco, California.
Source: Cancer immunology research [Cancer Immunol Res] 2026 May 04; Vol. 14 (5), pp. 718-732.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE
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  Data: VSIG4 Restricts Hepatocellular Carcinoma Control by Suppressing Tumor-Specific CD8+ T-cell Immunity in the Tumor Microenvironment.
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  Data: <searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; Department of Cancer Immunology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Bhela+S%22">Bhela S</searchLink>; Department of Cancer Immunology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Sharma+M%22">Sharma M</searchLink>; Department of Research Biology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Protti+G%22">Protti G</searchLink>; Department of Computational Biology and Translation, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Luoh+SM%22">Luoh SM</searchLink>; Department of Cancer Immunology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Cancer Immunology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Firmino+NS%22">Firmino NS</searchLink>; Department of Cancer Immunology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Dasoveanu+DC%22">Dasoveanu DC</searchLink>; Department of Cancer Immunology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Chan+C%22">Chan C</searchLink>; Department of Research Pathology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Ibarra-Lopez+V%22">Ibarra-Lopez V</searchLink>; Department of Research Pathology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Foo+C%22">Foo C</searchLink>; Department of Research Pathology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Jesudason+R%22">Jesudason R</searchLink>; Department of Research Pathology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Rost+S%22">Rost S</searchLink>; Department of Research Pathology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Scholl+T%22">Scholl T</searchLink>; Department of Research Support Facility, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Ziai+J%22">Ziai J</searchLink>; Department of Research Pathology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Comps-Agrar+L%22">Comps-Agrar L</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Translational Medicine Oncology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Müller+S%22">Müller S</searchLink>; Department of Computational Biology and Translation, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Shaw+AS%22">Shaw AS</searchLink>; Department of Research Biology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Turley+SJ%22">Turley SJ</searchLink>; Department of Immunology and Regenerative Medicine, Genentech, South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Fu+W%22">Fu W</searchLink>; Department of Cancer Immunology, Genentech, South San Francisco, California.
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  Data: <searchLink fieldCode="JN" term="%22101614637%22">Cancer immunology research</searchLink> [Cancer Immunol Res] 2026 May 04; Vol. 14 (5), pp. 718-732.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101614637 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2326-6074 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223266066%22">23266066 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Immunol Res <i>Subsets: </i>MEDLINE
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