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Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In Vivo.

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Title: Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In Vivo.
Authors: Burghardt T; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Thalmayr S; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.; Center for NanoScience (CeNS), LMU Munich, 80799 Munich, Germany., Obeser L; Pharmaceutical Chemistry, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Pöhmerer J; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Yazdi M; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Höhn M; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Völkl M; Pharmaceutical Biology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Sieber-Schäfer F; Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Zahler S; Pharmaceutical Biology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Merkel OM; Center for NanoScience (CeNS), LMU Munich, 80799 Munich, Germany.; Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Merk D; Pharmaceutical Chemistry, Department of Pharmacy, LMU Munich, 81377 Munich, Germany., Wagner E; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.; Center for NanoScience (CeNS), LMU Munich, 80799 Munich, Germany.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 Mar 11; Vol. 148 (9), pp. 9449-9464. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In Vivo.
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  Data: <searchLink fieldCode="AU" term="%22Burghardt+T%22">Burghardt T</searchLink>; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Thalmayr+S%22">Thalmayr S</searchLink>; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.; Center for NanoScience (CeNS), LMU Munich, 80799 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Obeser+L%22">Obeser L</searchLink>; Pharmaceutical Chemistry, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pöhmerer+J%22">Pöhmerer J</searchLink>; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Yazdi+M%22">Yazdi M</searchLink>; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Höhn+M%22">Höhn M</searchLink>; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Völkl+M%22">Völkl M</searchLink>; Pharmaceutical Biology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sieber-Schäfer+F%22">Sieber-Schäfer F</searchLink>; Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zahler+S%22">Zahler S</searchLink>; Pharmaceutical Biology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Merkel+OM%22">Merkel OM</searchLink>; Center for NanoScience (CeNS), LMU Munich, 80799 Munich, Germany.; Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Merk+D%22">Merk D</searchLink>; Pharmaceutical Chemistry, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+E%22">Wagner E</searchLink>; Pharmaceutical Biotechnology, Department of Pharmacy, LMU Munich, 81377 Munich, Germany.; Center for NanoScience (CeNS), LMU Munich, 80799 Munich, Germany.
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  Data: <searchLink fieldCode="JN" term="%227503056%22">Journal of the American Chemical Society</searchLink> [J Am Chem Soc] 2026 Mar 11; Vol. 148 (9), pp. 9449-9464. <i>Date of Electronic Publication: </i>2026 Feb 25.
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