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Plasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot study.

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Title: Plasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot study.
Authors: Tschirhart M; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France., Curtiaud A; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France., Abou Rjeily R; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France., Merdji H; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France., Demiselle J; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France., Severac F; Groupe Méthodes en Recherche Clinique (GMRC), Hôpitaux Universitaires de Strasbourg, Strasbourg, France., Guerin D; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France., Caçao M; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France., El Ghazouani F; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France., Angles-Cano E; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France., Toti F; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France., Meziani F; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France., Helms J; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France. julie.helms@chru-strasbourg.fr.; Université de Strasbourg (UNISTRA), Strasbourg, France. julie.helms@chru-strasbourg.fr.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France. julie.helms@chru-strasbourg.fr.
Source: Intensive care medicine [Intensive Care Med] 2026 Mar; Vol. 52 (3), pp. 456-465. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
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  Data: Plasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot study.
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  Data: <searchLink fieldCode="AU" term="%22Tschirhart+M%22">Tschirhart M</searchLink>; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Curtiaud+A%22">Curtiaud A</searchLink>; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Abou+Rjeily+R%22">Abou Rjeily R</searchLink>; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Merdji+H%22">Merdji H</searchLink>; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Demiselle+J%22">Demiselle J</searchLink>; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Severac+F%22">Severac F</searchLink>; Groupe Méthodes en Recherche Clinique (GMRC), Hôpitaux Universitaires de Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Guerin+D%22">Guerin D</searchLink>; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Caçao+M%22">Caçao M</searchLink>; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France.<br /><searchLink fieldCode="AU" term="%22El+Ghazouani+F%22">El Ghazouani F</searchLink>; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Angles-Cano+E%22">Angles-Cano E</searchLink>; Université Paris Cité, INSERM UMR_S 1144, Équipe 4, Optimisation Thérapeutique en Neuropharmacologie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Toti+F%22">Toti F</searchLink>; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Meziani+F%22">Meziani F</searchLink>; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France.; Université de Strasbourg (UNISTRA), Strasbourg, France.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Helms+J%22">Helms J</searchLink>; INSERM (French National Institute of Health and Medical Research) UMR 1260, Regenerative Nanomedicine (RNM), Strasbourg, France. julie.helms@chru-strasbourg.fr.; Université de Strasbourg (UNISTRA), Strasbourg, France. julie.helms@chru-strasbourg.fr.; Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Fédération Hospitalo-Universitaire TARGET, Strasbourg, France. julie.helms@chru-strasbourg.fr.
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  Data: <searchLink fieldCode="JN" term="%227704851%22">Intensive care medicine</searchLink> [Intensive Care Med] 2026 Mar; Vol. 52 (3), pp. 456-465. <i>Date of Electronic Publication: </i>2026 Feb 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7704851 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203424642%22">03424642 </searchLink><i>NLM ISO Abbreviation: </i>Intensive Care Med <i>Subsets: </i>MEDLINE
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