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Heterologous prime-boost immunization of AAV-based neoantigen cancer vaccine induces anti-tumor immunity to inhibit tumor growth and relapse.

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Title: Heterologous prime-boost immunization of AAV-based neoantigen cancer vaccine induces anti-tumor immunity to inhibit tumor growth and relapse.
Authors: Huang CH; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chen JY; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan., Chang HY; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, HsinChu, Taiwan., Hong WZ; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan., Jiang YW; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan., Lee CY; Innovation Frontier Institute of Research for Science and Technology, National Taipei University of Technology, Taipei, Taiwan.; Department of Electrical Engineering, National Taipei University of Technology, Taipei, Taiwan., Wu CH; Bioinformatics and Biostatistics Core, Centers of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan., Lin YS; Department of Chest Surgery, China Medical University Hospital, Taichung, Taiwan., Tsai YY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan., Kao WL; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan., Chao KSC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan., Huang KC; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Office of Research and Development, Asia University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Feb 25; Vol. 75 (3). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Heterologous prime-boost immunization of AAV-based neoantigen cancer vaccine induces anti-tumor immunity to inhibit tumor growth and relapse.
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  Data: <searchLink fieldCode="AU" term="%22Huang+CH%22">Huang CH</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+HY%22">Chang HY</searchLink>; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, HsinChu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hong+WZ%22">Hong WZ</searchLink>; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jiang+YW%22">Jiang YW</searchLink>; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+CY%22">Lee CY</searchLink>; Innovation Frontier Institute of Research for Science and Technology, National Taipei University of Technology, Taipei, Taiwan.; Department of Electrical Engineering, National Taipei University of Technology, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CH%22">Wu CH</searchLink>; Bioinformatics and Biostatistics Core, Centers of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YS%22">Lin YS</searchLink>; Department of Chest Surgery, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+YY%22">Tsai YY</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+WL%22">Kao WL</searchLink>; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chao+KSC%22">Chao KSC</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KC%22">Huang KC</searchLink>; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.; Office of Research and Development, Asia University, Taichung, Taiwan. chihyang0425@mail.cmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%228605732%22">Cancer immunology, immunotherapy : CII</searchLink> [Cancer Immunol Immunother] 2026 Feb 25; Vol. 75 (3). <i>Date of Electronic Publication: </i>2026 Feb 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>8605732 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0851 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203407004%22">03407004 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Immunol Immunother <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00262-026-04336-9
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              Text: 2026 Feb 25
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              Y: 2026
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