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Disentangling on and off-target binding in flortaucipir PET: a voxel-to-voxel P-tau, ferric iron, and MAO-B histology-to-flortaucipir PET comparison.

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Title: Disentangling on and off-target binding in flortaucipir PET: a voxel-to-voxel P-tau, ferric iron, and MAO-B histology-to-flortaucipir PET comparison.
Authors: Chen Y; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Departments of Laboratory Medicine and Pathology and Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.; Department of Quantitative Health Science, Mayo Clinic, Jacksonville, FL, 32224, USA., La Joie R; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA., Pereira FL; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Departments of Laboratory Medicine and Pathology and Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.; Department of Quantitative Health Science, Mayo Clinic, Jacksonville, FL, 32224, USA., Blazhenets G; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA., Zhu L; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Departments of Laboratory Medicine and Pathology and Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.; Department of Quantitative Health Science, Mayo Clinic, Jacksonville, FL, 32224, USA., Spina S; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA., Seeley WW; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA., Heinsen H; Institute of Forensic Medicine, Julius-Maximilians-Universität, 97078, Würzburg, Germany., Ushizima D; Center for Advanced Mathematics for Energy Research Applications, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Tosun D; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94107, USA., Rabinovici GD; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94107, USA., Grinberg LT; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA. grinberg.lea@mayo.edu.; Departments of Laboratory Medicine and Pathology and Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. grinberg.lea@mayo.edu.
Source: Acta neuropathologica [Acta Neuropathol] 2026 Feb 25; Vol. 151 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Disentangling on and off-target binding in flortaucipir PET: a voxel-to-voxel P-tau, ferric iron, and MAO-B histology-to-flortaucipir PET comparison.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Departments of Laboratory Medicine and Pathology and Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.; Department of Quantitative Health Science, Mayo Clinic, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22La+Joie+R%22">La Joie R</searchLink>; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Pereira+FL%22">Pereira FL</searchLink>; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Departments of Laboratory Medicine and Pathology and Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.; Department of Quantitative Health Science, Mayo Clinic, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Blazhenets+G%22">Blazhenets G</searchLink>; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Departments of Laboratory Medicine and Pathology and Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.; Department of Quantitative Health Science, Mayo Clinic, Jacksonville, FL, 32224, USA.<br /><searchLink fieldCode="AU" term="%22Spina+S%22">Spina S</searchLink>; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Seeley+WW%22">Seeley WW</searchLink>; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Heinsen+H%22">Heinsen H</searchLink>; Institute of Forensic Medicine, Julius-Maximilians-Universität, 97078, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ushizima+D%22">Ushizima D</searchLink>; Center for Advanced Mathematics for Energy Research Applications, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.<br /><searchLink fieldCode="AU" term="%22Tosun+D%22">Tosun D</searchLink>; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94107, USA.<br /><searchLink fieldCode="AU" term="%22Rabinovici+GD%22">Rabinovici GD</searchLink>; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94107, USA.<br /><searchLink fieldCode="AU" term="%22Grinberg+LT%22">Grinberg LT</searchLink>; Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA. grinberg.lea@mayo.edu.; Departments of Laboratory Medicine and Pathology and Neuroscience, Mayo Clinic Florida, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA. grinberg.lea@mayo.edu.
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