Efficacy and Harms of Opioid Analgesics for Acute Pain: Overview of Systematic Reviews and Meta-analyses.

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Title: Efficacy and Harms of Opioid Analgesics for Acute Pain: Overview of Systematic Reviews and Meta-analyses.
Authors: Mathieson S; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Sydney School of Pharmacy, University of Sydney, A15, Science Rd, Camperdown, NSW, 2050, Australia., Zadro JR; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia., Narayan SW; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia., McLachlan AJ; Sydney School of Pharmacy, University of Sydney, A15, Science Rd, Camperdown, NSW, 2050, Australia., Ballantyne JC; University of Washington Medical Centre, University of Washington, 1959 NE Pacific Street, Seattle, Washington, USA., Blyth FM; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia., Day RO; St Vincent's Clinical Campus, School of Medicine, St Vincent's Hospital, University of New South Wales, Level 5, de Lacy Building, Darlinghurst, NSW, 2010, Australia., Maher CG; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia., McLachlan H; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia., Lin CC; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia., Kamper SJ; Sydney School of Health Sciences, University of Sydney, Susan Wakil Health Building, Western Ave, Camperdown, NSW, 2050, Australia.; Nepean Blue Mountains Local Health District, 62 Derby St, Kingswood, NSW, 2747, Australia., Abdel Shaheed C; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia. christina.abdelshaheed@sydney.edu.au.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia. christina.abdelshaheed@sydney.edu.au.
Source: Drugs [Drugs] 2026 Apr; Vol. 86 (4), pp. 533-550. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 7600076 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1950 (Electronic) Linking ISSN: 00126667 NLM ISO Abbreviation: Drugs Subsets: MEDLINE
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  Data: Efficacy and Harms of Opioid Analgesics for Acute Pain: Overview of Systematic Reviews and Meta-analyses.
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  Data: <searchLink fieldCode="AU" term="%22Mathieson+S%22">Mathieson S</searchLink>; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Sydney School of Pharmacy, University of Sydney, A15, Science Rd, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Zadro+JR%22">Zadro JR</searchLink>; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Narayan+SW%22">Narayan SW</searchLink>; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22McLachlan+AJ%22">McLachlan AJ</searchLink>; Sydney School of Pharmacy, University of Sydney, A15, Science Rd, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Ballantyne+JC%22">Ballantyne JC</searchLink>; University of Washington Medical Centre, University of Washington, 1959 NE Pacific Street, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Blyth+FM%22">Blyth FM</searchLink>; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Day+RO%22">Day RO</searchLink>; St Vincent's Clinical Campus, School of Medicine, St Vincent's Hospital, University of New South Wales, Level 5, de Lacy Building, Darlinghurst, NSW, 2010, Australia.<br /><searchLink fieldCode="AU" term="%22Maher+CG%22">Maher CG</searchLink>; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22McLachlan+H%22">McLachlan H</searchLink>; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Lin+CC%22">Lin CC</searchLink>; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Kamper+SJ%22">Kamper SJ</searchLink>; Sydney School of Health Sciences, University of Sydney, Susan Wakil Health Building, Western Ave, Camperdown, NSW, 2050, Australia.; Nepean Blue Mountains Local Health District, 62 Derby St, Kingswood, NSW, 2747, Australia.<br /><searchLink fieldCode="AU" term="%22Abdel+Shaheed+C%22">Abdel Shaheed C</searchLink>; Sydney School of Public Health, University of Sydney, Edward Ford Building, A27 Fisher Rd, Camperdown, NSW, 2050, Australia. christina.abdelshaheed@sydney.edu.au.; Institute for Musculoskeletal Health, Royal Prince Alfred Hospital (C39), Sydney Local Health District, Level 10N, King George V Building, Camperdown, NSW, 2050, Australia. christina.abdelshaheed@sydney.edu.au.
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