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The vaccine platform used for COVID-19 primary immunization shapes the quality of the human B cell response to a vaccine boost.

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Title: The vaccine platform used for COVID-19 primary immunization shapes the quality of the human B cell response to a vaccine boost.
Authors: Lima NS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., McCormick L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; Quantitative Virology and Evolution Unit, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; Paleovirology Laboratory, Department of Biology, University of Oxford, Oxford OX1 2JD, UK., Li S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; Baylor College of Medicine, Houston, TX 77030, USA., Wake CG; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Subramanian R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Spangler A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Pinto Y; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Catalano W; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Henry AR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Laboune F; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Teng IT; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Lyke KE; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Atmar RL; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Deming ME; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Jackson LA; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA., Branche AR; Department of Medicine, Division of Infectious Diseases, University of Rochester, Rochester, NY 14609, USA., Rostad CA; Department of Pediatrics and Center for Childhood Infections and Vaccines, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA., Martin JM; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Johnston CM; Department of Medicine, University of Washington, Seattle, WA 98195, USA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer, Seattle, WA 98109, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Rupp RE; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA., Kottkamp AC; NYU Langone Vaccine Center and Division of Infectious Diseases and Immunology, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA., Brady RC; Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Backer M; NYU Langone Hospital, Long Island Vaccine Center Research Clinic and Division of Infectious Disease, Department of Medicine, NYU Long Island School of Medicine, Mineola, NY 11501, USA., Edupuganti S; Hope Clinic of the Emory Vaccine Center, Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Decatur, GA 30307, USA., Posavad CM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer, Seattle, WA 98109, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Roberts PC; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA., Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Andrews S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Schramm CA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Douek DC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Corporate Authors: 21-0012 Study Group, 21-0012 Study Group collaborators
Source: Science translational medicine [Sci Transl Med] 2026 Feb 25; Vol. 18 (838), pp. eaeb9837. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The vaccine platform used for COVID-19 primary immunization shapes the quality of the human B cell response to a vaccine boost.
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  Data: <searchLink fieldCode="AU" term="%22Lima+NS%22">Lima NS</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22McCormick+L%22">McCormick L</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; Quantitative Virology and Evolution Unit, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; Paleovirology Laboratory, Department of Biology, University of Oxford, Oxford OX1 2JD, UK.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Wake+CG%22">Wake CG</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Subramanian+R%22">Subramanian R</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Spangler+A%22">Spangler A</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Pinto+Y%22">Pinto Y</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Catalano+W%22">Catalano W</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Henry+AR%22">Henry AR</searchLink>; 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Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.<br /><searchLink fieldCode="AU" term="%22Kottkamp+AC%22">Kottkamp AC</searchLink>; NYU Langone Vaccine Center and Division of Infectious Diseases and Immunology, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Brady+RC%22">Brady RC</searchLink>; Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.<br /><searchLink fieldCode="AU" term="%22Backer+M%22">Backer M</searchLink>; NYU Langone Hospital, Long Island Vaccine Center Research Clinic and Division of Infectious Disease, Department of Medicine, NYU Long Island School of Medicine, Mineola, NY 11501, USA.<br /><searchLink fieldCode="AU" term="%22Edupuganti+S%22">Edupuganti S</searchLink>; Hope Clinic of the Emory Vaccine Center, Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Decatur, GA 30307, USA.<br /><searchLink fieldCode="AU" term="%22Posavad+CM%22">Posavad CM</searchLink>; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer, Seattle, WA 98109, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+PC%22">Roberts PC</searchLink>; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20982, USA.<br /><searchLink fieldCode="AU" term="%22Kwong+PD%22">Kwong PD</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Andrews+S%22">Andrews S</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Schramm+CA%22">Schramm CA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Douek+DC%22">Douek DC</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
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