Systemic Inflammation and CAR-T Specific Toxicities as Major Drivers of Nonrelapse Mortality: Analysis from the Italian Prospective Observational CART-SIE Study.
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| Title: | Systemic Inflammation and CAR-T Specific Toxicities as Major Drivers of Nonrelapse Mortality: Analysis from the Italian Prospective Observational CART-SIE Study. |
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| Authors: | Barone A; University of Milan, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milano, Italy; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Stella F; University of Milan, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milano, Italy. Electronic address: federico.stella@unimi.it., Ljevar S; Department of Data Science, Unit of Biostatistics for Clinical Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Casadei B; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Bologna, Italy., Bramanti S; Transplantation Unit Department of Oncology and Haematology, IRCCS Humanitas Research Hospital, Milan, Italy., Chiusolo P; Dipartimento di Scienze Ematologiche e di laboratorio, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Sezione di Ematologia, Ematologia e Trapianto, Università Cattolica del Sacro Cuore, Rome, Italy., Rocco AD; Department of Translational and Precision Medicine Hematology, Univ Sapienza Roma, Rome, Italy., Tisi MC; Hematology Unit, San Bortolo Hospital, Vicenza, Italy., Cutini I; SOD Ematologia, AAD Trapianto di midollo osseo, Ospedale Careggi, Firenze, Italy., Angelillo P; IRCCS San Raffaele Scientific Institute, Milan, Italy., Martino M; Department of Hemato-Oncology and Radiotherapy, Hematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Grande Ospedale Metropolitano 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Musso M; Dipartimento Oncologico 'La Maddalena' Palermo, UOC di Oncoematologia e TMO, Reggio Calabria, Italy., Farina M; Unit of Blood Disease and Bone Marrow Transplantation, and Unit of Hematology, University of Brescia, ASST Spedali Civili di Brescia, Bergamo, Italy., Pennisi M; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Barbui AM; Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Freilone R; Division of Hematology, AOU 'Città della Salute e della Scienza di Torino', Turin, Italy., Olivieri J; Clinica Ematologica, Centro Trapianti e Terapie Cellulari 'Carlo Melzi', Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy., Grillo G; Dipartimento di Ematologia e Trapianto di midollo, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy., Musto P; Department of Precision and Regenerative Medicine and Ionian Area, 'Aldo Moro' University School of Medicine, Bari, Italy; Unit of Hematology and Stem Cell Transplantation, AOUC Policlinico, Bari, Italy., Saraceni F; Clinica di Ematologia - Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy., Krampera M; Department of Engineering for Innovative Medicine (DIMI), Hematology and Bone Marrow Transplant Unit, Section of Biomedicine of Innovation, University of Verona, Verona, Italy., Brunello L; SCDU Ematologia, AOU SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy., Castellino A; Division of Hematology - AO S. Croce e Carle, Cuneo and Laboratory of Blood Tumor Immunology, Molecular Biotechnology Center 'Guido Tarone', University of Torino, Torino, Italy., Ragaini S; Division of Hematology, University Hospital A.O.U. 'Città della Salute e della Scienza', Turin, Italy; Division of Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy., Arcaini L; Department of Molecular Medicine, University of Pavia, Pavia, Italy; Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Chiappella A; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Guidetti A; University of Milan, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milano, Italy; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Dodero A; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Miceli R; Department of Data Science, Unit of Biostatistics for Clinical Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Zinzani P; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Bologna, Italy; Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy., Corradini P; University of Milan, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milano, Italy; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. |
| Source: | Transplantation and cellular therapy [Transplant Cell Ther] 2026 Jun; Vol. 32 (6), pp. 674.e1-674.e14. Date of Electronic Publication: 2026 Feb 23. |
| Publication Type: | Journal Article; Observational Study; Multicenter Study |
| Journal Info: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101774629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-6367 (Electronic) Linking ISSN: 26666367 NLM ISO Abbreviation: Transplant Cell Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41740850 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Systemic Inflammation and CAR-T Specific Toxicities as Major Drivers of Nonrelapse Mortality: Analysis from the Italian Prospective Observational CART-SIE Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Barone+A%22">Barone A</searchLink>; University of Milan, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milano, Italy; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Stella+F%22">Stella F</searchLink>; University of Milan, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milano, Italy. Electronic address: federico.stella@unimi.it.<br /><searchLink fieldCode="AU" term="%22Ljevar+S%22">Ljevar S</searchLink>; Department of Data Science, Unit of Biostatistics for Clinical Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Casadei+B%22">Casadei B</searchLink>; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Bramanti+S%22">Bramanti S</searchLink>; Transplantation Unit Department of Oncology and Haematology, IRCCS Humanitas Research Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Chiusolo+P%22">Chiusolo P</searchLink>; Dipartimento di Scienze Ematologiche e di laboratorio, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Sezione di Ematologia, Ematologia e Trapianto, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rocco+AD%22">Rocco AD</searchLink>; Department of Translational and Precision Medicine Hematology, Univ Sapienza Roma, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Tisi+MC%22">Tisi MC</searchLink>; Hematology Unit, San Bortolo Hospital, Vicenza, Italy.<br /><searchLink fieldCode="AU" term="%22Cutini+I%22">Cutini I</searchLink>; SOD Ematologia, AAD Trapianto di midollo osseo, Ospedale Careggi, Firenze, Italy.<br /><searchLink fieldCode="AU" term="%22Angelillo+P%22">Angelillo P</searchLink>; IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Martino+M%22">Martino M</searchLink>; Department of Hemato-Oncology and Radiotherapy, Hematology and Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Grande Ospedale Metropolitano 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Musso+M%22">Musso M</searchLink>; Dipartimento Oncologico 'La Maddalena' Palermo, UOC di Oncoematologia e TMO, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Farina+M%22">Farina M</searchLink>; Unit of Blood Disease and Bone Marrow Transplantation, and Unit of Hematology, University of Brescia, ASST Spedali Civili di Brescia, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Pennisi+M%22">Pennisi M</searchLink>; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Barbui+AM%22">Barbui AM</searchLink>; Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Freilone+R%22">Freilone R</searchLink>; Division of Hematology, AOU 'Città della Salute e della Scienza di Torino', Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Olivieri+J%22">Olivieri J</searchLink>; Clinica Ematologica, Centro Trapianti e Terapie Cellulari 'Carlo Melzi', Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Grillo+G%22">Grillo G</searchLink>; Dipartimento di Ematologia e Trapianto di midollo, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Musto+P%22">Musto P</searchLink>; Department of Precision and Regenerative Medicine and Ionian Area, 'Aldo Moro' University School of Medicine, Bari, Italy; Unit of Hematology and Stem Cell Transplantation, AOUC Policlinico, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Saraceni+F%22">Saraceni F</searchLink>; Clinica di Ematologia - Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Krampera+M%22">Krampera M</searchLink>; Department of Engineering for Innovative Medicine (DIMI), Hematology and Bone Marrow Transplant Unit, Section of Biomedicine of Innovation, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Brunello+L%22">Brunello L</searchLink>; SCDU Ematologia, AOU SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.<br /><searchLink fieldCode="AU" term="%22Castellino+A%22">Castellino A</searchLink>; Division of Hematology - AO S. Croce e Carle, Cuneo and Laboratory of Blood Tumor Immunology, Molecular Biotechnology Center 'Guido Tarone', University of Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Ragaini+S%22">Ragaini S</searchLink>; Division of Hematology, University Hospital A.O.U. 'Città della Salute e della Scienza', Turin, Italy; Division of Hematology, Department of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Arcaini+L%22">Arcaini L</searchLink>; Department of Molecular Medicine, University of Pavia, Pavia, Italy; Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Chiappella+A%22">Chiappella A</searchLink>; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Guidetti+A%22">Guidetti A</searchLink>; University of Milan, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milano, Italy; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Dodero+A%22">Dodero A</searchLink>; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Miceli+R%22">Miceli R</searchLink>; Department of Data Science, Unit of Biostatistics for Clinical Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Zinzani+P%22">Zinzani P</searchLink>; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Bologna, Italy; Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Corradini+P%22">Corradini P</searchLink>; University of Milan, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Milano, Italy; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101774629%22">Transplantation and cellular therapy</searchLink> [Transplant Cell Ther] 2026 Jun; Vol. 32 (6), pp. 674.e1-674.e14. <i>Date of Electronic Publication: </i>2026 Feb 23. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Observational Study; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%22">Elsevier Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101774629 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-6367 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226666367%22">26666367 </searchLink><i>NLM ISO Abbreviation: </i>Transplant Cell Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41740850 |
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