SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.

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Title: SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.
Authors: Zhu W; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Pan L; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Cui X; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Russo AC; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Ray R; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Pederson B; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Wei X; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Lin LL; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Torres M; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Hafner H; Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA., Gregg B; Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA.; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Shrestha N; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Liu C; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Naji A; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Arvan P; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Sandoval DA; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Pediatrics, Nutrition Section, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lindberg I; Department of Anatomy and Neurobiology, University of Maryland-Baltimore, Baltimore, MD, USA., Qi L; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. xvr2hm@virginia.edu.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA. xvr2hm@virginia.edu.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA. xvr2hm@virginia.edu., Reinert RB; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. reinertr@med.umich.edu.
Source: Nature communications [Nat Commun] 2026 Feb 25; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-69928-6