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SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.

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Title: SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.
Authors: Zhu W; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Pan L; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Cui X; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Russo AC; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Ray R; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Pederson B; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Wei X; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Lin LL; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Torres M; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA., Hafner H; Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA., Gregg B; Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA.; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Shrestha N; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Liu C; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Naji A; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Arvan P; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Sandoval DA; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Pediatrics, Nutrition Section, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lindberg I; Department of Anatomy and Neurobiology, University of Maryland-Baltimore, Baltimore, MD, USA., Qi L; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. xvr2hm@virginia.edu.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA. xvr2hm@virginia.edu.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA. xvr2hm@virginia.edu., Reinert RB; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. reinertr@med.umich.edu.
Source: Nature communications [Nat Commun] 2026 Feb 25; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pan+L%22">Pan L</searchLink>; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Cui+X%22">Cui X</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Russo+AC%22">Russo AC</searchLink>; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ray+R%22">Ray R</searchLink>; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pederson+B%22">Pederson B</searchLink>; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Wei+X%22">Wei X</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+LL%22">Lin LL</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Torres+M%22">Torres M</searchLink>; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Hafner+H%22">Hafner H</searchLink>; Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Gregg+B%22">Gregg B</searchLink>; Department of Pediatrics, Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA.; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Shrestha+N%22">Shrestha N</searchLink>; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Naji+A%22">Naji A</searchLink>; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Arvan+P%22">Arvan P</searchLink>; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sandoval+DA%22">Sandoval DA</searchLink>; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Pediatrics, Nutrition Section, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Lindberg+I%22">Lindberg I</searchLink>; Department of Anatomy and Neurobiology, University of Maryland-Baltimore, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Qi+L%22">Qi L</searchLink>; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. xvr2hm@virginia.edu.; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA. xvr2hm@virginia.edu.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA. xvr2hm@virginia.edu.<br /><searchLink fieldCode="AU" term="%22Reinert+RB%22">Reinert RB</searchLink>; Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. reinertr@med.umich.edu.
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