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A disease model resource reveals core principles of tissue-specific cancer evolution.

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Title: A disease model resource reveals core principles of tissue-specific cancer evolution.
Authors: Mueller S; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., de Andrade Krätzig N; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Tschurtschenthaler M; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Silva MG; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Thordsen C; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Trozzo R; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Simon P; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Saab F; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany., Kaltenbacher T; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Zukowska M; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany., Lucarelli D; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.; Institute of Computational Biology, Helmholtz Munich, Munich, Germany., Öllinger R; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Griger J; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Groß N; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Groll T; Comparative Experimental Pathology, School of Medicine and Health, TU Munich, Munich, Germany.; Institute of Pathology, School of Medicine and Health, TU Munich, Munich, Germany., Löprich J; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Zaurito AE; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany., Schömig LR; Klinik für Innere Medizin II, Universitätsklinikum Freiburg, Freiburg, Germany., Bugter JM; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Bärthel S; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany., Falcomatà C; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany., Strong A; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK., Brandt C; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK., Najajreh M; Center for Functional Protein Assemblies, TU Munich, Garching, Germany.; Center for Organoid Systems (COS), TU Munich, Garching, Germany.; Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.; Translational Pancreatic Cancer Research Center, Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany., Papargyriou A; Center for Functional Protein Assemblies, TU Munich, Garching, Germany.; Center for Organoid Systems (COS), TU Munich, Garching, Germany.; Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.; Translational Pancreatic Cancer Research Center, Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.; Institute of Stem Cell Research, Helmholtz Munich, Munich, Germany., Maresch R; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Collins KAN; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Sailer D; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Schneeweis C; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany., Burger S; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Fröhlich LM; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.; Department of Translational Oncology, German Cancer Research Center (DKFZ), LMU Munich, Munich, Germany., Klement C; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Belka A; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Montero JJ; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany., Jungwirth U; Newcastle Drug Discovery Group, Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Reichert M; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Functional Protein Assemblies, TU Munich, Garching, Germany.; Center for Organoid Systems (COS), TU Munich, Garching, Germany.; Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.; Translational Pancreatic Cancer Research Center, Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany., Moser M; Institute of Experimental Hematology, School of Medicine and Health, TU Munich, Munich, Germany., Neumann J; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Vassiliou G; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK., Cadiñanos J; Fundación Centro Médico de Asturias, Oviedo, Spain., Varela I; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, Santander, Spain., Marr C; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany., Alonso DF; Center for Molecular and Translational Oncology (COMTra), National University of Quilmes (UNQ), Buenos Aires, Argentina.; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina., Lollini PL; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.; IRCCS Azienda Ospedaliera Universitaria di Bologna, Bologna, Italy., Zhao J; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Chesler L; Division of Clinical Studies, The Institute of Cancer Research (ICR) and Royal Marsden NHS Trust, Sutton, UK., Isacke CM; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK., Riedel A; Mildred Scheel Early Career Centre, University Hospital of Würzburg, Würzburg, Germany., Braun CJ; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ), Heidelberg, Germany., Sos ML; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.; Department of Translational Oncology, German Cancer Research Center (DKFZ), LMU Munich, Munich, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Beleggia F; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Mildred Scheel School of Oncology Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Reinhardt HC; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Hematology and Stem Cell Transplantation, West German Cancer Center Essen, University Hospital Essen, Essen, Germany., Musteanu M; Centro de Investigación Biomédica en Red de Cáncer, Instituto de Salud Carlos III, Madrid, Spain.; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain., Barbacid M; Centro de Investigación Biomédica en Red de Cáncer, Instituto de Salud Carlos III, Madrid, Spain.; Experimental Oncology Group, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain., Quante M; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Klinik für Innere Medizin II, Universitätsklinikum Freiburg, Freiburg, Germany., Schmidt-Supprian M; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Experimental Hematology, School of Medicine and Health, TU Munich, Munich, Germany., Schneider G; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Clinical Research Unit 5002, KFO5002, University Medical Center Göttingen, Göttingen, Germany.; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Clare S; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK., Lawley TD; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK., Dougan G; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK.; Centre for Translational Stem Cell Biology, Hong Kong, China., Steiger K; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Comparative Experimental Pathology, School of Medicine and Health, TU Munich, Munich, Germany.; Institute of Pathology, School of Medicine and Health, TU Munich, Munich, Germany., Conte N; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK., Bradley A; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK., Rad L; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Saur D; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany., Rad R; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany. roland.rad@tum.de.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany. roland.rad@tum.de.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. roland.rad@tum.de.
Source: Nature [Nature] 2026 May; Vol. 653 (8113), pp. 265-276. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: A disease model resource reveals core principles of tissue-specific cancer evolution.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22de+Andrade+Krätzig+N%22">de Andrade Krätzig N</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Tschurtschenthaler+M%22">Tschurtschenthaler M</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Silva+MG%22">Silva MG</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Thordsen+C%22">Thordsen C</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Trozzo+R%22">Trozzo R</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Simon+P%22">Simon P</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Saab+F%22">Saab F</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kaltenbacher+T%22">Kaltenbacher T</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zukowska+M%22">Zukowska M</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lucarelli+D%22">Lucarelli D</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.; Institute of Computational Biology, Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Öllinger+R%22">Öllinger R</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Griger+J%22">Griger J</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Groß+N%22">Groß N</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Groll+T%22">Groll T</searchLink>; Comparative Experimental Pathology, School of Medicine and Health, TU Munich, Munich, Germany.; Institute of Pathology, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Löprich+J%22">Löprich J</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zaurito+AE%22">Zaurito AE</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schömig+LR%22">Schömig LR</searchLink>; Klinik für Innere Medizin II, Universitätsklinikum Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bugter+JM%22">Bugter JM</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bärthel+S%22">Bärthel S</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Falcomatà+C%22">Falcomatà C</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Strong+A%22">Strong A</searchLink>; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Brandt+C%22">Brandt C</searchLink>; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Najajreh+M%22">Najajreh M</searchLink>; Center for Functional Protein Assemblies, TU Munich, Garching, Germany.; Center for Organoid Systems (COS), TU Munich, Garching, Germany.; Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.; Translational Pancreatic Cancer Research Center, Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Papargyriou+A%22">Papargyriou A</searchLink>; Center for Functional Protein Assemblies, TU Munich, Garching, Germany.; Center for Organoid Systems (COS), TU Munich, Garching, Germany.; Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.; Translational Pancreatic Cancer Research Center, Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.; Institute of Stem Cell Research, Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Maresch+R%22">Maresch R</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Collins+KAN%22">Collins KAN</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sailer+D%22">Sailer D</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schneeweis+C%22">Schneeweis C</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Burger+S%22">Burger S</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Fröhlich+LM%22">Fröhlich LM</searchLink>; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.; Department of Translational Oncology, German Cancer Research Center (DKFZ), LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Klement+C%22">Klement C</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Belka+A%22">Belka A</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Montero+JJ%22">Montero JJ</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jungwirth+U%22">Jungwirth U</searchLink>; Newcastle Drug Discovery Group, Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Reichert+M%22">Reichert M</searchLink>; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Functional Protein Assemblies, TU Munich, Garching, Germany.; Center for Organoid Systems (COS), TU Munich, Garching, Germany.; Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.; Translational Pancreatic Cancer Research Center, Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Moser+M%22">Moser M</searchLink>; Institute of Experimental Hematology, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Neumann+J%22">Neumann J</searchLink>; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Vassiliou+G%22">Vassiliou G</searchLink>; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cadiñanos+J%22">Cadiñanos J</searchLink>; Fundación Centro Médico de Asturias, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Varela+I%22">Varela I</searchLink>; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, Santander, Spain.<br /><searchLink fieldCode="AU" term="%22Marr+C%22">Marr C</searchLink>; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of AI for Health, Helmholtz Munich, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Alonso+DF%22">Alonso DF</searchLink>; Center for Molecular and Translational Oncology (COMTra), National University of Quilmes (UNQ), Buenos Aires, Argentina.; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Lollini+PL%22">Lollini PL</searchLink>; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.; IRCCS Azienda Ospedaliera Universitaria di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chesler+L%22">Chesler L</searchLink>; Division of Clinical Studies, The Institute of Cancer Research (ICR) and Royal Marsden NHS Trust, Sutton, UK.<br /><searchLink fieldCode="AU" term="%22Isacke+CM%22">Isacke CM</searchLink>; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Riedel+A%22">Riedel A</searchLink>; Mildred Scheel Early Career Centre, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Braun+CJ%22">Braun CJ</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Sos+ML%22">Sos ML</searchLink>; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.; Department of Translational Oncology, German Cancer Research Center (DKFZ), LMU Munich, Munich, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Beleggia+F%22">Beleggia F</searchLink>; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Mildred Scheel School of Oncology Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhardt+HC%22">Reinhardt HC</searchLink>; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Hematology and Stem Cell Transplantation, West German Cancer Center Essen, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Musteanu+M%22">Musteanu M</searchLink>; Centro de Investigación Biomédica en Red de Cáncer, Instituto de Salud Carlos III, Madrid, Spain.; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Barbacid+M%22">Barbacid M</searchLink>; Centro de Investigación Biomédica en Red de Cáncer, Instituto de Salud Carlos III, Madrid, Spain.; Experimental Oncology Group, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Quante+M%22">Quante M</searchLink>; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Klinik für Innere Medizin II, Universitätsklinikum Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt-Supprian+M%22">Schmidt-Supprian M</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Experimental Hematology, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+G%22">Schneider G</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Clinical Research Unit 5002, KFO5002, University Medical Center Göttingen, Göttingen, Germany.; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Clare+S%22">Clare S</searchLink>; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Lawley+TD%22">Lawley TD</searchLink>; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Dougan+G%22">Dougan G</searchLink>; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK.; Centre for Translational Stem Cell Biology, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Steiger+K%22">Steiger K</searchLink>; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Comparative Experimental Pathology, School of Medicine and Health, TU Munich, Munich, Germany.; Institute of Pathology, School of Medicine and Health, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Conte+N%22">Conte N</searchLink>; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Bradley+A%22">Bradley A</searchLink>; Genome Campus, Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Rad+L%22">Rad L</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Saur+D%22">Saur D</searchLink>; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany.; Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Institute of Experimental Cancer Therapy, School of Medicine and Health, TU Munich, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine II, TUM University Hospital, TU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rad+R%22">Rad R</searchLink>; Institute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TU Munich, Munich, Germany. roland.rad@tum.de.; Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, TU Munich, Munich, Germany. roland.rad@tum.de.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. roland.rad@tum.de.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 May; Vol. 653 (8113), pp. 265-276. <i>Date of Electronic Publication: </i>2026 Feb 25.
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