Nitric Oxide-Mediated S-Nitrosylation of TSC2 Drives mTOR dysregulation across Shank3 and Cntnap2 Models of Autism Spectrum Disorder.

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Title: Nitric Oxide-Mediated S-Nitrosylation of TSC2 Drives mTOR dysregulation across Shank3 and Cntnap2 Models of Autism Spectrum Disorder.
Authors: Ojha SK; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 9112002, Jerusalem, Israel., Kartawy M; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 9112002, Jerusalem, Israel., Hamoudi W; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 9112002, Jerusalem, Israel., Tripathi MK; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 9112002, Jerusalem, Israel., Aran A; Department of Pediatrics, Shaare Zedek Medical Center, 9103102, Jerusalem, Israel.; Faculty of Medicine, Hebrew University of Jerusalem, 9112002, Jerusalem, Israel., Amal H; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, 9112002, Jerusalem, Israel. Haitham.amal@mail.huji.ac.il.; The Rosamund Stone Zander and Hansjoerg Wyss Translational Neuroscience Center, Boston Children's Hospital, Harvard Medical School, Harvard University, Boston, 02115, MA, USA. Haitham.amal@mail.huji.ac.il.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jul; Vol. 31 (7), pp. 3710-3725. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1476-5578
DOI:10.1038/s41380-026-03514-6