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Pathway activity profiling can predict neoadjuvant endocrine therapy response in HR+ HER2- postmenopausal early stage breast cancer.

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Title: Pathway activity profiling can predict neoadjuvant endocrine therapy response in HR+ HER2- postmenopausal early stage breast cancer.
Authors: de Gruil N; Leiden University Medical Center, Leiden, The Netherlands., de Groot AF; Leiden University Medical Center, Leiden, The Netherlands., Wesseling-Rozendaal Y; InnoSIGN B.V., Eindhoven, The Netherlands., Keizer D; InnoSIGN B.V., Eindhoven, The Netherlands., Koekenbier CS; Leiden University Medical Center, Leiden, The Netherlands., Vermeer S; InnoSIGN B.V., Eindhoven, The Netherlands., Cohen D; Leiden University Medical Center, Leiden, The Netherlands., Heijns JB; Department of Medical Oncology, Amphia, Breda, The Netherlands., Mandigers CMPW; Department of Medical Oncology, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands., van de Wouw AJ; Department of Medical Oncology, VieCuri Medical Center, Venlo, The Netherlands., Cloos-van Balen M; Department of Medical Oncology, Groene Hart Hospital, Gouda, The Netherlands., Ropela JA; Department of Medical Oncology, St. Jansdal, Harderwijk, The Netherlands., Oosterkamp HM; Department of Medical Oncology, Haaglanden Medical Center, The Hague, The Netherlands., van Bekkum ML; Department of Medical Oncology, Reinier de Graaf Gasthuis, Delft, The Netherlands., Houtsma D; Department of Medical Oncology, HAGA Hospital, The Hague, The Netherlands., Biezen ED; InnoSIGN B.V., Eindhoven, The Netherlands., Liefers GJ; Leiden University Medical Center, Leiden, The Netherlands., Linn SC; Antoni van Leeuwenhoek Hospital, Amsterdam, and University Medical Center Utrecht, Utrecht, The Netherlands., Kroep JR; Leiden University Medical Center, Leiden, The Netherlands. j.r.kroep@lumc.nl.
Source: Breast cancer research : BCR [Breast Cancer Res] 2026 Feb 25; Vol. 28 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pathway activity profiling can predict neoadjuvant endocrine therapy response in HR+ HER2- postmenopausal early stage breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22de+Gruil+N%22">de Gruil N</searchLink>; Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Groot+AF%22">de Groot AF</searchLink>; Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wesseling-Rozendaal+Y%22">Wesseling-Rozendaal Y</searchLink>; InnoSIGN B.V., Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Keizer+D%22">Keizer D</searchLink>; InnoSIGN B.V., Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Koekenbier+CS%22">Koekenbier CS</searchLink>; Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vermeer+S%22">Vermeer S</searchLink>; InnoSIGN B.V., Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cohen+D%22">Cohen D</searchLink>; Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Heijns+JB%22">Heijns JB</searchLink>; Department of Medical Oncology, Amphia, Breda, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mandigers+CMPW%22">Mandigers CMPW</searchLink>; Department of Medical Oncology, Canisius Wilhelmina Ziekenhuis, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Wouw+AJ%22">van de Wouw AJ</searchLink>; Department of Medical Oncology, VieCuri Medical Center, Venlo, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cloos-van+Balen+M%22">Cloos-van Balen M</searchLink>; Department of Medical Oncology, Groene Hart Hospital, Gouda, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ropela+JA%22">Ropela JA</searchLink>; Department of Medical Oncology, St. Jansdal, Harderwijk, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Oosterkamp+HM%22">Oosterkamp HM</searchLink>; Department of Medical Oncology, Haaglanden Medical Center, The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Bekkum+ML%22">van Bekkum ML</searchLink>; Department of Medical Oncology, Reinier de Graaf Gasthuis, Delft, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Houtsma+D%22">Houtsma D</searchLink>; Department of Medical Oncology, HAGA Hospital, The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Biezen+ED%22">Biezen ED</searchLink>; InnoSIGN B.V., Eindhoven, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Liefers+GJ%22">Liefers GJ</searchLink>; Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Linn+SC%22">Linn SC</searchLink>; Antoni van Leeuwenhoek Hospital, Amsterdam, and University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kroep+JR%22">Kroep JR</searchLink>; Leiden University Medical Center, Leiden, The Netherlands. j.r.kroep@lumc.nl.
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  Data: <searchLink fieldCode="JN" term="%22100927353%22">Breast cancer research : BCR</searchLink> [Breast Cancer Res] 2026 Feb 25; Vol. 28 (1). <i>Date of Electronic Publication: </i>2026 Feb 25.
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  Data: Journal Article; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100927353 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1465-542X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214655411%22">14655411 </searchLink><i>NLM ISO Abbreviation: </i>Breast Cancer Res <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 25
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