TRKB-based signature identifies high-risk squamous cell carcinoma cases and TRKB blockade reprograms tumor and stromal cells toward suppressive phenotypes.
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| Title: | TRKB-based signature identifies high-risk squamous cell carcinoma cases and TRKB blockade reprograms tumor and stromal cells toward suppressive phenotypes. |
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| Authors: | Bartolocci V; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy., Capone A; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy., Monetta R; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy., Di Meo E; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy., Arcano S; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy., Valente C; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy., Campagna D; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy., Teson M; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy., Mancini M; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.; Biochemistry Laboratory, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy., Di Lella G; Skin Cancer Center, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy., Abeni D; Clinical Epidemiology Unit, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Italy, Rome., Fania L; Skin Cancer Center, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy., Ricci F; Anatomic Pathology Department, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy., Gomes V; Anatomic Pathology Department, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy., Scaglione GL; Bioinformatics Unit, Istituto Dermopatico Dell'Immacolata, IDI-IRCCS, 00167, Rome, Italy., Mastroeni S; National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy., Candi E; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.; Biochemistry Laboratory, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy., Dellambra E; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy. e.dellambra@idi.it. |
| Source: | Journal of biomedical science [J Biomed Sci] 2026 Feb 25; Vol. 33 (1). Date of Electronic Publication: 2026 Feb 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41742188 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: TRKB-based signature identifies high-risk squamous cell carcinoma cases and TRKB blockade reprograms tumor and stromal cells toward suppressive phenotypes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bartolocci+V%22">Bartolocci V</searchLink>; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Capone+A%22">Capone A</searchLink>; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Monetta+R%22">Monetta R</searchLink>; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Meo+E%22">Di Meo E</searchLink>; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Arcano+S%22">Arcano S</searchLink>; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Valente+C%22">Valente C</searchLink>; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Campagna+D%22">Campagna D</searchLink>; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Teson+M%22">Teson M</searchLink>; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mancini+M%22">Mancini M</searchLink>; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.; Biochemistry Laboratory, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Lella+G%22">Di Lella G</searchLink>; Skin Cancer Center, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Abeni+D%22">Abeni D</searchLink>; Clinical Epidemiology Unit, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Italy, Rome.<br /><searchLink fieldCode="AU" term="%22Fania+L%22">Fania L</searchLink>; Skin Cancer Center, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ricci+F%22">Ricci F</searchLink>; Anatomic Pathology Department, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gomes+V%22">Gomes V</searchLink>; Anatomic Pathology Department, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Scaglione+GL%22">Scaglione GL</searchLink>; Bioinformatics Unit, Istituto Dermopatico Dell'Immacolata, IDI-IRCCS, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mastroeni+S%22">Mastroeni S</searchLink>; National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Candi+E%22">Candi E</searchLink>; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.; Biochemistry Laboratory, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, 00167, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Dellambra+E%22">Dellambra E</searchLink>; Laboratory of Molecular and Cell Biology, Istituto Dermopatico Dell'Immacolata IDI-IRCCS, Via dei Monti di Creta, 104, 00167, Rome, Italy. e.dellambra@idi.it. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229421567%22">Journal of biomedical science</searchLink> [J Biomed Sci] 2026 Feb 25; Vol. 33 (1). <i>Date of Electronic Publication: </i>2026 Feb 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421567 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1423-0127 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210217770%22">10217770 </searchLink><i>NLM ISO Abbreviation: </i>J Biomed Sci <i>Subsets: </i>MEDLINE; In Process |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41742188 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12929-026-01227-0 Languages: – Code: eng Text: English Titles: – TitleFull: TRKB-based signature identifies high-risk squamous cell carcinoma cases and TRKB blockade reprograms tumor and stromal cells toward suppressive phenotypes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bartolocci V – PersonEntity: Name: NameFull: Capone A – PersonEntity: Name: NameFull: Monetta R – PersonEntity: Name: NameFull: Di Meo E – PersonEntity: Name: NameFull: Arcano S – PersonEntity: Name: NameFull: Valente C – PersonEntity: Name: NameFull: Campagna D – PersonEntity: Name: NameFull: Teson M – PersonEntity: Name: NameFull: Mancini M – PersonEntity: Name: NameFull: Di Lella G – PersonEntity: Name: NameFull: Abeni D – PersonEntity: Name: NameFull: Fania L – PersonEntity: Name: NameFull: Ricci F – PersonEntity: Name: NameFull: Gomes V – PersonEntity: Name: NameFull: Scaglione GL – PersonEntity: Name: NameFull: Mastroeni S – PersonEntity: Name: NameFull: Candi E – PersonEntity: Name: NameFull: Dellambra E IsPartOfRelationships: – BibEntity: Dates: – D: 25 M: 02 Text: 2026 Feb 25 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1423-0127 Numbering: – Type: volume Value: 33 – Type: issue Value: 1 Titles: – TitleFull: Journal of biomedical science Type: main |
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