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Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups.

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Title: Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups.
Authors: Hartmann AM; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany., Bastian L; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany., Barz MJ; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany., Haas J; Division of Pediatric Oncology and Children's Research Center University Children's Hospital Zurich Zurich Switzerland., Amelunxen E; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany., Ehm P; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany., Lenk L; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany., Kotrova M; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Beder T; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Steffen FD; Division of Pediatric Oncology and Children's Research Center University Children's Hospital Zurich Zurich Switzerland., Rauwolf K; Division of Pediatric Oncology and Children's Research Center University Children's Hospital Zurich Zurich Switzerland., Wolgast N; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany., Bendig S; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany., Bozzetti C; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Alten J; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany., Mondal M; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Institute for Clinical Molecular Biology, University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany., Rademacher A; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany., Heymann J; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany., Walter W; MLL Munich Leukemia Laboratory Munich Germany., Haferlach C; MLL Munich Leukemia Laboratory Munich Germany., Ströh AS; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany., Bergmann AK; Clinical Genetics and Genomic Medicine University Hospital Würzburg Würzburg Germany., Burmeister T; Department of Hematology, Oncology and Cancer Immunology CVK, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany., Gökbuget N; Department of Medicine II, Hematology/Oncology Goethe University Hospital Frankfurt am Main Germany., Bornhauser B; Division of Pediatric Oncology and Children's Research Center University Children's Hospital Zurich Zurich Switzerland., Bourquin JP; Division of Pediatric Oncology and Children's Research Center University Children's Hospital Zurich Zurich Switzerland., Brüggemann M; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany., Schrappe M; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany., Cario G; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany., Baldus CD; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.
Source: HemaSphere [Hemasphere] 2026 Feb 19; Vol. 10 (2), pp. e70324. Date of Electronic Publication: 2026 Feb 19 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups.
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  Data: <searchLink fieldCode="AU" term="%22Hartmann+AM%22">Hartmann AM</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Bastian+L%22">Bastian L</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Barz+MJ%22">Barz MJ</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Haas+J%22">Haas J</searchLink>; Division of Pediatric Oncology and Children's Research Center University Children's Hospital Zurich Zurich Switzerland.<br /><searchLink fieldCode="AU" term="%22Amelunxen+E%22">Amelunxen E</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Ehm+P%22">Ehm P</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Lenk+L%22">Lenk L</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; 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Division of Pediatric Oncology and Children's Research Center University Children's Hospital Zurich Zurich Switzerland.<br /><searchLink fieldCode="AU" term="%22Wolgast+N%22">Wolgast N</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Bendig+S%22">Bendig S</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Bozzetti+C%22">Bozzetti C</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Alten+J%22">Alten J</searchLink>; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Mondal+M%22">Mondal M</searchLink>; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Institute for Clinical Molecular Biology, University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Rademacher+A%22">Rademacher A</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Heymann+J%22">Heymann J</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Walter+W%22">Walter W</searchLink>; MLL Munich Leukemia Laboratory Munich Germany.<br /><searchLink fieldCode="AU" term="%22Haferlach+C%22">Haferlach C</searchLink>; MLL Munich Leukemia Laboratory Munich Germany.<br /><searchLink fieldCode="AU" term="%22Ströh+AS%22">Ströh AS</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Bergmann+AK%22">Bergmann AK</searchLink>; Clinical Genetics and Genomic Medicine University Hospital Würzburg Würzburg Germany.<br /><searchLink fieldCode="AU" term="%22Burmeister+T%22">Burmeister T</searchLink>; Department of Hematology, Oncology and Cancer Immunology CVK, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.<br /><searchLink fieldCode="AU" term="%22Gökbuget+N%22">Gökbuget N</searchLink>; Department of Medicine II, Hematology/Oncology Goethe University Hospital Frankfurt am Main Germany.<br /><searchLink fieldCode="AU" term="%22Bornhauser+B%22">Bornhauser B</searchLink>; Division of Pediatric Oncology and Children's Research Center University Children's Hospital Zurich Zurich Switzerland.<br /><searchLink fieldCode="AU" term="%22Bourquin+JP%22">Bourquin JP</searchLink>; Division of Pediatric Oncology and Children's Research Center University Children's Hospital Zurich Zurich Switzerland.<br /><searchLink fieldCode="AU" term="%22Brüggemann+M%22">Brüggemann M</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Schrappe+M%22">Schrappe M</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Cario+G%22">Cario G</searchLink>; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.; Department of Pediatrics I, Pediatric Hematology/Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.<br /><searchLink fieldCode="AU" term="%22Baldus+CD%22">Baldus CD</searchLink>; Medical Department II, Hematology and Oncology University Medical Center Schleswig-Holstein, Campus Kiel Kiel Germany.; University Cancer Center Schleswig-Holstein (UCCSH) University Medical Center Schleswig-Holstein Kiel Germany.; Clinical Research Unit CATCH ALL KFO 5010 Kiel Germany.
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