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Long-Term Protective Immune Responses Induced by rBCG-RBD/rRBD Heterologous Prime/Boost Immunization Strategy: Fusion of RBD-Wuhan with LTB Adjuvant Induces Cross-Reactivity with SARS-CoV-2 Variant Omicron.

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Title: Long-Term Protective Immune Responses Induced by rBCG-RBD/rRBD Heterologous Prime/Boost Immunization Strategy: Fusion of RBD-Wuhan with LTB Adjuvant Induces Cross-Reactivity with SARS-CoV-2 Variant Omicron.
Authors: Gaboardi GC; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil., Trentini MM; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil., Kanno AI; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil., Moraes L; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil., Januzzi AD; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil., Pereira LR; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil., Dias GBM; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil., Huergo LF; Universidade Federal do Paraná, Setor Litoral, Matinhos 83260-000, Brazil., Oliveira SC; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-060, Brazil., Bafica A; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil., Leite LCC; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil.
Source: Vaccines [Vaccines (Basel)] 2026 Jan 27; Vol. 14 (2). Date of Electronic Publication: 2026 Jan 27.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Long-Term Protective Immune Responses Induced by rBCG-RBD/rRBD Heterologous Prime/Boost Immunization Strategy: Fusion of RBD-Wuhan with LTB Adjuvant Induces Cross-Reactivity with SARS-CoV-2 Variant Omicron.
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  Data: <searchLink fieldCode="AU" term="%22Gaboardi+GC%22">Gaboardi GC</searchLink>; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Trentini+MM%22">Trentini MM</searchLink>; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Kanno+AI%22">Kanno AI</searchLink>; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Moraes+L%22">Moraes L</searchLink>; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Januzzi+AD%22">Januzzi AD</searchLink>; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+LR%22">Pereira LR</searchLink>; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Dias+GBM%22">Dias GBM</searchLink>; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Huergo+LF%22">Huergo LF</searchLink>; Universidade Federal do Paraná, Setor Litoral, Matinhos 83260-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Oliveira+SC%22">Oliveira SC</searchLink>; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo 05508-060, Brazil.<br /><searchLink fieldCode="AU" term="%22Bafica+A%22">Bafica A</searchLink>; Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Leite+LCC%22">Leite LCC</searchLink>; Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05503-900, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101629355%22">Vaccines</searchLink> [Vaccines (Basel)] 2026 Jan 27; Vol. 14 (2). <i>Date of Electronic Publication: </i>2026 Jan 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+AG%22">MDPI AG </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101629355 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2076-393X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222076393X%22">2076393X </searchLink><i>NLM ISO Abbreviation: </i>Vaccines (Basel) <i>Subsets: </i>PubMed not MEDLINE
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            – D: 27
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              Text: 2026 Jan 27
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