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Protocol for a Randomized Clinical Trial to Evaluate Not Routinely Measuring Gastric Residual Volume to Guide Enteral Feeding Versus Routine Measurement in Mechanically Ventilated Critically Ill Children (GASTRIC-PICU).

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Title: Protocol for a Randomized Clinical Trial to Evaluate Not Routinely Measuring Gastric Residual Volume to Guide Enteral Feeding Versus Routine Measurement in Mechanically Ventilated Critically Ill Children (GASTRIC-PICU).
Authors: Orzol M; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Chang I; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Laing E; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Peters MJ; Infection, Immunity and Inflammation Department, University College London, London, United Kingdom.; Paediatric Intensive Care Unit (PICU), Great Ormond Street Hospital NHS Foundation Trust and NIHR Biomedical Research Centre, London, United Kingdom., Edwards JE; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Ferrando-Vivas P; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Camsooksai J; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Khatun J; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Lampro L; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Parke M; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Sedgwick H; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Au C; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Harrison D; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Latten L; Department of Nutrition and Dietetics, Alder Hey Children's Hospital, Liverpool, United Kingdom., Menzies J; Paediatric Intensive Care Unit, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom.; College of Health, Science and Society, University of the West of England, Blackberry Hill, Bristol, United Kingdom., Marino LV; Department of Research and Development, Division - Medical Directorate, South West Yorkshire Partnership Teaching NHS Foundation Trust, Field Head Hospital, Wakefield, United Kingdom., Brown KL; Paediatric Intensive Care Unit (PICU), Great Ormond Street Hospital NHS Foundation Trust and NIHR Biomedical Research Centre, London, United Kingdom., Hall NJ; University Surgery Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Woolfall K; Public Health Policy and Systems, Institute of Population Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom., Sadique Z; Department of Health Services Research and Policy, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom., Veale L; Parent representative, United Kingdom., Schlapbach LJ; Department of Intensive Care and Neonatology, and Children`s Research Center, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland.; Child Health Research Centre, University of Queensland, Brisbane, QLD, Australia., Mouncey P; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom., Valla FV; Nutrition Support Team, Endocrinology and Nutrition Department, Hospices Civils de Lyon, Lyon, France., Tume LN; Department of Nutrition and Dietetics, Alder Hey Children's Hospital, Liverpool, United Kingdom.; Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk, United Kingdom.
Source: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2026 May 01; Vol. 27 (5), pp. 655-665. Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Equivalence Trial
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100954653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-7535 (Print) Linking ISSN: 15297535 NLM ISO Abbreviation: Pediatr Crit Care Med Subsets: MEDLINE
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  Data: Protocol for a Randomized Clinical Trial to Evaluate Not Routinely Measuring Gastric Residual Volume to Guide Enteral Feeding Versus Routine Measurement in Mechanically Ventilated Critically Ill Children (GASTRIC-PICU).
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  Data: <searchLink fieldCode="AU" term="%22Orzol+M%22">Orzol M</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chang+I%22">Chang I</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Laing+E%22">Laing E</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Peters+MJ%22">Peters MJ</searchLink>; Infection, Immunity and Inflammation Department, University College London, London, United Kingdom.; Paediatric Intensive Care Unit (PICU), Great Ormond Street Hospital NHS Foundation Trust and NIHR Biomedical Research Centre, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Edwards+JE%22">Edwards JE</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ferrando-Vivas+P%22">Ferrando-Vivas P</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Camsooksai+J%22">Camsooksai J</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Khatun+J%22">Khatun J</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lampro+L%22">Lampro L</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Parke+M%22">Parke M</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sedgwick+H%22">Sedgwick H</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Au+C%22">Au C</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Harrison+D%22">Harrison D</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Latten+L%22">Latten L</searchLink>; Department of Nutrition and Dietetics, Alder Hey Children's Hospital, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Menzies+J%22">Menzies J</searchLink>; Paediatric Intensive Care Unit, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom.; College of Health, Science and Society, University of the West of England, Blackberry Hill, Bristol, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Marino+LV%22">Marino LV</searchLink>; Department of Research and Development, Division - Medical Directorate, South West Yorkshire Partnership Teaching NHS Foundation Trust, Field Head Hospital, Wakefield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brown+KL%22">Brown KL</searchLink>; Paediatric Intensive Care Unit (PICU), Great Ormond Street Hospital NHS Foundation Trust and NIHR Biomedical Research Centre, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hall+NJ%22">Hall NJ</searchLink>; University Surgery Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Woolfall+K%22">Woolfall K</searchLink>; Public Health Policy and Systems, Institute of Population Health, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sadique+Z%22">Sadique Z</searchLink>; Department of Health Services Research and Policy, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Veale+L%22">Veale L</searchLink>; Parent representative, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Schlapbach+LJ%22">Schlapbach LJ</searchLink>; Department of Intensive Care and Neonatology, and Children`s Research Center, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland.; Child Health Research Centre, University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Mouncey+P%22">Mouncey P</searchLink>; Clinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Valla+FV%22">Valla FV</searchLink>; Nutrition Support Team, Endocrinology and Nutrition Department, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Tume+LN%22">Tume LN</searchLink>; Department of Nutrition and Dietetics, Alder Hey Children's Hospital, Liverpool, United Kingdom.; Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk, United Kingdom.
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