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Study protocol for a randomized clinical pilot trial investigating feasibility and efficacy of augmenting a virtual reality-assisted intervention targeting auditory verbal hallucinations with biofeedback: The Neuro-VR study.

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Title: Study protocol for a randomized clinical pilot trial investigating feasibility and efficacy of augmenting a virtual reality-assisted intervention targeting auditory verbal hallucinations with biofeedback: The Neuro-VR study.
Authors: Habla AF; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Soleim SB; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Due AS; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Tinglef TH; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Eskelund K; Oticon A/S, Smørum, Denmark., Díaz-I-Calvete J; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark., Larsen KM; Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark., Kristensen TD; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Ebdrup BH; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nordentoft M; Copenhagen Research Center on Mental Health (CORE), Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Lyngholm D; EXP360, Zug, Switzerland., Miskowiak KW; Neurocognition and Emotion Across Disorders of the Brain Centre (NEAD), Psychiatric Centre Copenhagen, Frederiksberg Hospital, Copenhagen, Denmark.; Department of Psychology, University of Copenhagen, Copenhagen, Denmark., Ambrosen KS; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark., Birkedal Glenthøj L; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Source: PloS one [PLoS One] 2026 Feb 26; Vol. 21 (2), pp. e0333716. Date of Electronic Publication: 2026 Feb 26 (Print Publication: 2026).
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Study protocol for a randomized clinical pilot trial investigating feasibility and efficacy of augmenting a virtual reality-assisted intervention targeting auditory verbal hallucinations with biofeedback: The Neuro-VR study.
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  Data: <searchLink fieldCode="AU" term="%22Habla+AF%22">Habla AF</searchLink>; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Soleim+SB%22">Soleim SB</searchLink>; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Due+AS%22">Due AS</searchLink>; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Tinglef+TH%22">Tinglef TH</searchLink>; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Eskelund+K%22">Eskelund K</searchLink>; Oticon A/S, Smørum, Denmark.<br /><searchLink fieldCode="AU" term="%22Díaz-I-Calvete+J%22">Díaz-I-Calvete J</searchLink>; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Larsen+KM%22">Larsen KM</searchLink>; Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kristensen+TD%22">Kristensen TD</searchLink>; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Ebdrup+BH%22">Ebdrup BH</searchLink>; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nordentoft+M%22">Nordentoft M</searchLink>; Copenhagen Research Center on Mental Health (CORE), Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Lyngholm+D%22">Lyngholm D</searchLink>; EXP360, Zug, Switzerland.<br /><searchLink fieldCode="AU" term="%22Miskowiak+KW%22">Miskowiak KW</searchLink>; Neurocognition and Emotion Across Disorders of the Brain Centre (NEAD), Psychiatric Centre Copenhagen, Frederiksberg Hospital, Copenhagen, Denmark.; Department of Psychology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ambrosen+KS%22">Ambrosen KS</searchLink>; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Birkedal+Glenthøj+L%22">Birkedal Glenthøj L</searchLink>; VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Feb 26; Vol. 21 (2), pp. e0333716. <i>Date of Electronic Publication: </i>2026 Feb 26 (<i>Print Publication: </i>2026).
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