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Integrated Chronic In Vivo and In Vitro Screens Uncover NFIL3 as a Driver of T-cell Dysfunction.

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Title: Integrated Chronic In Vivo and In Vitro Screens Uncover NFIL3 as a Driver of T-cell Dysfunction.
Authors: Jain N; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York., Shi Y; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York., May C; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Pediatric Hematology and Oncology, University Children's Hospital Tübingen, University of Tübingen, Tübingen, Germany., Mitra S; Computational & Systems Biology Program, Sloan Kettering Institute, New York, New York., Bucher P; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Pediatric Hematology and Oncology, University Children's Hospital Tübingen, University of Tübingen, Tübingen, Germany., Dobrin A; Department of Immunology, Sunnybrook Research Institute, University of Toronto, Toronto, Canada., Zhao Z; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York., Hanina S; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York., Rajasekhar VK; Orthopedic Service, Department of Surgery, Memorial Hospital, New York, New York., Yao Y; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York., Mansilla-Soto J; Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, Florida.; Department of Bioengineering, H. Lee Moffitt Cancer Center, Tampa, Florida.; Department of BMT and Cellular Immunotherapy, H. Lee Moffitt Cancer Center, Tampa, Florida., Leibold J; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen, Germany., Leslie CS; Computational & Systems Biology Program, Sloan Kettering Institute, New York, New York., Sánchez-Rivera FJ; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts., Feucht J; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Pediatric Hematology and Oncology, University Children's Hospital Tübingen, University of Tübingen, Tübingen, Germany., Sadelain M; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York.
Source: Cancer discovery [Cancer Discov] 2026 Jul 01; Vol. 16 (7), pp. 1456-1471.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Jain+N%22">Jain N</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22May+C%22">May C</searchLink>; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Pediatric Hematology and Oncology, University Children's Hospital Tübingen, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Mitra+S%22">Mitra S</searchLink>; Computational & Systems Biology Program, Sloan Kettering Institute, New York, New York.<br /><searchLink fieldCode="AU" term="%22Bucher+P%22">Bucher P</searchLink>; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Pediatric Hematology and Oncology, University Children's Hospital Tübingen, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Dobrin+A%22">Dobrin A</searchLink>; Department of Immunology, Sunnybrook Research Institute, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Hanina+S%22">Hanina S</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Rajasekhar+VK%22">Rajasekhar VK</searchLink>; Orthopedic Service, Department of Surgery, Memorial Hospital, New York, New York.<br /><searchLink fieldCode="AU" term="%22Yao+Y%22">Yao Y</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Mansilla-Soto+J%22">Mansilla-Soto J</searchLink>; Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, Florida.; Department of Bioengineering, H. Lee Moffitt Cancer Center, Tampa, Florida.; Department of BMT and Cellular Immunotherapy, H. Lee Moffitt Cancer Center, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Leibold+J%22">Leibold J</searchLink>; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Leslie+CS%22">Leslie CS</searchLink>; Computational & Systems Biology Program, Sloan Kettering Institute, New York, New York.<br /><searchLink fieldCode="AU" term="%22Sánchez-Rivera+FJ%22">Sánchez-Rivera FJ</searchLink>; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Feucht+J%22">Feucht J</searchLink>; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Department of Pediatric Hematology and Oncology, University Children's Hospital Tübingen, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Sadelain+M%22">Sadelain M</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York.
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