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Surrogate endpoints for survival in KEYNOTE-585: neoadjuvant/adjuvant pembrolizumab plus chemotherapy versus placebo plus chemotherapy for gastric or gastroesophageal junction adenocarcinoma.

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Title: Surrogate endpoints for survival in KEYNOTE-585: neoadjuvant/adjuvant pembrolizumab plus chemotherapy versus placebo plus chemotherapy for gastric or gastroesophageal junction adenocarcinoma.
Authors: Shitara K; National Cancer Center Hospital East, Kashiwa, Japan. Electronic address: kshitara@east.ncc.go.jp., Bang YJ; Seoul National University College of Medicine, Seoul, Republic of Korea., Wyrwicz LS; Maria Sklodowska-Curie National Cancer Research Institute, Warsaw, Poland., Rha SY; Yonsei University College of Medicine, Seoul, Republic of Korea., Oshima T; Kanagawa Cancer Center, Yokohama, Japan., Pietrantonio F; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Park YK; Chonnam National University Medical School, Hwasun, Republic of Korea., Lonardi S; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy., Yañez P; Universidad de La Frontera, James Lind Cancer Research Center, Temuco, Chile., Yen CJ; National Cheng Kung University, Tainan, Taiwan., Metges JP; CHU-Brest-Institut de Cancerologie et d'Hematologie ARPEGO Network, Brest, France., Garrido M; Clinica San Carlos de Apoquindo, Pontificia Universidad Católica, Santiago, Chile., Moehler M; Johannes-Gutenberg University Clinic, Mainz, Germany., Pelles-Avraham S; Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Yong WP; National University Cancer Institute Singapore (NCIS), Singapore., Spallanzani A; University Hospital of Modena, Modena, Italy., Jensen E; Merck & Co., Inc., Rahway, USA., Krishnan R; Merck & Co., Inc., Rahway, USA., Shih CS; Merck & Co., Inc., Rahway, USA., Al-Batran SE; Krankenhaus Nordwest, UCT-University Cancer Center, Frankfurt, Germany.
Source: ESMO open [ESMO Open] 2026 Mar; Vol. 11 (3), pp. 106090. Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Surrogate endpoints for survival in KEYNOTE-585: neoadjuvant/adjuvant pembrolizumab plus chemotherapy versus placebo plus chemotherapy for gastric or gastroesophageal junction adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Shitara+K%22">Shitara K</searchLink>; National Cancer Center Hospital East, Kashiwa, Japan. Electronic address: kshitara@east.ncc.go.jp.<br /><searchLink fieldCode="AU" term="%22Bang+YJ%22">Bang YJ</searchLink>; Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Wyrwicz+LS%22">Wyrwicz LS</searchLink>; Maria Sklodowska-Curie National Cancer Research Institute, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Rha+SY%22">Rha SY</searchLink>; Yonsei University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oshima+T%22">Oshima T</searchLink>; Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Pietrantonio+F%22">Pietrantonio F</searchLink>; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Park+YK%22">Park YK</searchLink>; Chonnam National University Medical School, Hwasun, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lonardi+S%22">Lonardi S</searchLink>; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Yañez+P%22">Yañez P</searchLink>; Universidad de La Frontera, James Lind Cancer Research Center, Temuco, Chile.<br /><searchLink fieldCode="AU" term="%22Yen+CJ%22">Yen CJ</searchLink>; National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Metges+JP%22">Metges JP</searchLink>; CHU-Brest-Institut de Cancerologie et d'Hematologie ARPEGO Network, Brest, France.<br /><searchLink fieldCode="AU" term="%22Garrido+M%22">Garrido M</searchLink>; Clinica San Carlos de Apoquindo, Pontificia Universidad Católica, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Moehler+M%22">Moehler M</searchLink>; Johannes-Gutenberg University Clinic, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Pelles-Avraham+S%22">Pelles-Avraham S</searchLink>; Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Yong+WP%22">Yong WP</searchLink>; National University Cancer Institute Singapore (NCIS), Singapore.<br /><searchLink fieldCode="AU" term="%22Spallanzani+A%22">Spallanzani A</searchLink>; University Hospital of Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Jensen+E%22">Jensen E</searchLink>; Merck & Co., Inc., Rahway, USA.<br /><searchLink fieldCode="AU" term="%22Krishnan+R%22">Krishnan R</searchLink>; Merck & Co., Inc., Rahway, USA.<br /><searchLink fieldCode="AU" term="%22Shih+CS%22">Shih CS</searchLink>; Merck & Co., Inc., Rahway, USA.<br /><searchLink fieldCode="AU" term="%22Al-Batran+SE%22">Al-Batran SE</searchLink>; Krankenhaus Nordwest, UCT-University Cancer Center, Frankfurt, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2026 Mar; Vol. 11 (3), pp. 106090. <i>Date of Electronic Publication: </i>2026 Feb 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101690685 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-7029 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220597029%22">20597029 </searchLink><i>NLM ISO Abbreviation: </i>ESMO Open <i>Subsets: </i>MEDLINE
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