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Effect of intranasal treatment with NAMPT-EVs on acetylated tau and cognitive function in mice with repeated controlled cortical injury.

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Title: Effect of intranasal treatment with NAMPT-EVs on acetylated tau and cognitive function in mice with repeated controlled cortical injury.
Authors: Chen W; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Wu ZC; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Lin L; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Huang S; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Jiang Q; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Huang H; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Xie YC; Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Huang LX; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China., Li G; Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, Guangdong, 510663, PR China., Fu QL; Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. Electronic address: fuqingl@mail.sysu.edu.cn., Pei Z; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. Electronic address: peizhong@mail.sysu.edu.cn., Yao X; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. Electronic address: yaoxiaol@mail.sysu.edu.cn.
Source: International immunopharmacology [Int Immunopharmacol] 2026 Apr 15; Vol. 175, pp. 116415. Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effect of intranasal treatment with NAMPT-EVs on acetylated tau and cognitive function in mice with repeated controlled cortical injury.
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  Data: <searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Wu+ZC%22">Wu ZC</searchLink>; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Jiang+Q%22">Jiang Q</searchLink>; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Xie+YC%22">Xie YC</searchLink>; Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Huang+LX%22">Huang LX</searchLink>; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, Guangdong, 510663, PR China.<br /><searchLink fieldCode="AU" term="%22Fu+QL%22">Fu QL</searchLink>; Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, PR China; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. Electronic address: fuqingl@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Pei+Z%22">Pei Z</searchLink>; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. Electronic address: peizhong@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; Department of Neurology, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, PR China. Electronic address: yaoxiaol@mail.sysu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>100965259 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-1705 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215675769%22">15675769 </searchLink><i>NLM ISO Abbreviation: </i>Int Immunopharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.intimp.2026.116415
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        Text: English
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              Text: 2026 Apr 15
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