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Targeting PCK1 to overcome CDK4/6 inhibitor resistance for breast cancer therapy.

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Title: Targeting PCK1 to overcome CDK4/6 inhibitor resistance for breast cancer therapy.
Authors: Wu CS; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Chen HF; Graduate Institutes of Cell Biology, China Medical University, Taichung, Taiwan., Huynh KT; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan., Huang WC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan., Li YC; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan., Chang WC; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan., Chang LC; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan., Jiang CL; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan., Huang KC; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan., Liu LC; Department of Breast Surgery, China Medical University Hospital, Taichung, Taiwan., Chao KSC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan., Hung MC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan; Institute of Biochemistry and Molecular Biology, China Medical University, Taichung, Taiwan; Department of Biotechnology, Asia University, Taichung, Taiwan. Electronic address: mhung@cmu.edu.tw.
Source: Cancer letters [Cancer Lett] 2026 May 01; Vol. 645, pp. 218349. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Targeting PCK1 to overcome CDK4/6 inhibitor resistance for breast cancer therapy.
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  Data: <searchLink fieldCode="AU" term="%22Wu+CS%22">Wu CS</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+HF%22">Chen HF</searchLink>; Graduate Institutes of Cell Biology, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huynh+KT%22">Huynh KT</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+WC%22">Huang WC</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+YC%22">Li YC</searchLink>; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+WC%22">Chang WC</searchLink>; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+LC%22">Chang LC</searchLink>; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jiang+CL%22">Jiang CL</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+KC%22">Huang KC</searchLink>; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+LC%22">Liu LC</searchLink>; Department of Breast Surgery, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chao+KSC%22">Chao KSC</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Proton Therapy and Science Center, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of Radiation Oncology, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+MC%22">Hung MC</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan; Institute of Biochemistry and Molecular Biology, China Medical University, Taichung, Taiwan; Department of Biotechnology, Asia University, Taichung, Taiwan. Electronic address: mhung@cmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%227600053%22">Cancer letters</searchLink> [Cancer Lett] 2026 May 01; Vol. 645, pp. 218349. <i>Date of Electronic Publication: </i>2026 Feb 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ireland%22">Elsevier Science Ireland </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7600053 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7980 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203043835%22">03043835 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.canlet.2026.218349
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      – Code: eng
        Text: English
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      – TitleFull: Targeting PCK1 to overcome CDK4/6 inhibitor resistance for breast cancer therapy.
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            – D: 01
              M: 05
              Text: 2026 May 01
              Type: published
              Y: 2026
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              Value: 645
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