Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial.
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| Title: | Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial. |
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| Authors: | Riggle BA; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Chamzas A; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Gopalakrishnan M; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, Maryland, USA., Nyirenda OM; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Nampota-Nkomba N; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.; Department of Internal Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi., Mallewa JE; Department of Internal Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi., Masonga R; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Manyozo C; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Zuze K; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Liomba AM; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi., Alt J; Johns Hopkins Drug Discovery, Johs Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA., Rais R; Johns Hopkins Drug Discovery, Johs Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA., Slusher B; Johns Hopkins Drug Discovery, Johs Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA., Moodley N; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA., Miller LH; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA., Pierce SK; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., O'Brien NF; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.; Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA., Laurens MB; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA., Postels DG; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.; Division of Neurology, The George Washington University, Children's National Hospital, Washington, District of Columbia, USA. |
| Source: | The Journal of infectious diseases [J Infect Dis] 2026 May 15; Vol. 233 (5), pp. e1226-e1237. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41748157 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Riggle+BA%22">Riggle BA</searchLink>; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Chamzas+A%22">Chamzas A</searchLink>; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Gopalakrishnan+M%22">Gopalakrishnan M</searchLink>; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Nyirenda+OM%22">Nyirenda OM</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Nampota-Nkomba+N%22">Nampota-Nkomba N</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.; Department of Internal Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Mallewa+JE%22">Mallewa JE</searchLink>; Department of Internal Medicine, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Masonga+R%22">Masonga R</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Manyozo+C%22">Manyozo C</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Zuze+K%22">Zuze K</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Liomba+AM%22">Liomba AM</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Alt+J%22">Alt J</searchLink>; Johns Hopkins Drug Discovery, Johs Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Rais+R%22">Rais R</searchLink>; Johns Hopkins Drug Discovery, Johs Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Slusher+B%22">Slusher B</searchLink>; Johns Hopkins Drug Discovery, Johs Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Moodley+N%22">Moodley N</searchLink>; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Miller+LH%22">Miller LH</searchLink>; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Pierce+SK%22">Pierce SK</searchLink>; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22O'Brien+NF%22">O'Brien NF</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.; Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Laurens+MB%22">Laurens MB</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Postels+DG%22">Postels DG</searchLink>; Blantyre Malaria Project, Kamuzu University of Health Sciences, Blantyre, Malawi.; Division of Neurology, The George Washington University, Children's National Hospital, Washington, District of Columbia, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220413675%22">The Journal of infectious diseases</searchLink> [J Infect Dis] 2026 May 15; Vol. 233 (5), pp. e1226-e1237. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0413675 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1537-6613 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221899%22">00221899 </searchLink><i>NLM ISO Abbreviation: </i>J Infect Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41748157 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/infdis/jiag121 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e1226 Titles: – TitleFull: Safety, Tolerability, and Pharmacokinetics of 6-Diazo-5-Oxo-L-Norleucine in Malawian Adults With and Without Malaria: A Phase 1 Dose-Escalation Clinical Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Riggle BA – PersonEntity: Name: NameFull: Chamzas A – PersonEntity: Name: NameFull: Gopalakrishnan M – PersonEntity: Name: NameFull: Nyirenda OM – PersonEntity: Name: NameFull: Nampota-Nkomba N – PersonEntity: Name: NameFull: Mallewa JE – PersonEntity: Name: NameFull: Masonga R – PersonEntity: Name: NameFull: Manyozo C – PersonEntity: Name: NameFull: Zuze K – PersonEntity: Name: NameFull: Liomba AM – PersonEntity: Name: NameFull: Alt J – PersonEntity: Name: NameFull: Rais R – PersonEntity: Name: NameFull: Slusher B – PersonEntity: Name: NameFull: Moodley N – PersonEntity: Name: NameFull: Miller LH – PersonEntity: Name: NameFull: Pierce SK – PersonEntity: Name: NameFull: O'Brien NF – PersonEntity: Name: NameFull: Laurens MB – PersonEntity: Name: NameFull: Postels DG IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 05 Text: 2026 May 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1537-6613 Numbering: – Type: volume Value: 233 – Type: issue Value: 5 Titles: – TitleFull: The Journal of infectious diseases Type: main |
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