Physicochemical and Proteolytic Barriers Limiting Activity of Cpl-1 and Pal Endolysins in Human Circulation.

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Title: Physicochemical and Proteolytic Barriers Limiting Activity of Cpl-1 and Pal Endolysins in Human Circulation.
Authors: Harhala MA; Institute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, 61-712 Poznan, Poland.; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland., Gembara K; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.; Research & Development Center, Regional Specialist Hospital, 51-124 Wroclaw, Poland., Rybicka I; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland., Kaźmierczak ZM; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.; Faculty of Medicine, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland., Miernikiewicz P; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland., Dąbrowska K; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.; Research & Development Center, Regional Specialist Hospital, 51-124 Wroclaw, Poland.; Faculty of Medicine, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.
Source: Current issues in molecular biology [Curr Issues Mol Biol] 2026 Feb 21; Vol. 48 (2). Date of Electronic Publication: 2026 Feb 21.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100931761 Publication Model: Electronic Cited Medium: Internet ISSN: 1467-3045 (Electronic) Linking ISSN: 14673037 NLM ISO Abbreviation: Curr Issues Mol Biol Subsets: PubMed not MEDLINE
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  Data: Physicochemical and Proteolytic Barriers Limiting Activity of Cpl-1 and Pal Endolysins in Human Circulation.
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  Data: <searchLink fieldCode="AU" term="%22Harhala+MA%22">Harhala MA</searchLink>; Institute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, 61-712 Poznan, Poland.; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Gembara+K%22">Gembara K</searchLink>; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.; Research & Development Center, Regional Specialist Hospital, 51-124 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Rybicka+I%22">Rybicka I</searchLink>; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Kaźmierczak+ZM%22">Kaźmierczak ZM</searchLink>; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.; Faculty of Medicine, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Miernikiewicz+P%22">Miernikiewicz P</searchLink>; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.<br /><searchLink fieldCode="AU" term="%22Dąbrowska+K%22">Dąbrowska K</searchLink>; Laboratory of Phage Molecular Biology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.; Research & Development Center, Regional Specialist Hospital, 51-124 Wroclaw, Poland.; Faculty of Medicine, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.
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  Data: <searchLink fieldCode="JN" term="%22100931761%22">Current issues in molecular biology</searchLink> [Curr Issues Mol Biol] 2026 Feb 21; Vol. 48 (2). <i>Date of Electronic Publication: </i>2026 Feb 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI%22">MDPI </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>100931761 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1467-3045 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214673037%22">14673037 </searchLink><i>NLM ISO Abbreviation: </i>Curr Issues Mol Biol <i>Subsets: </i>PubMed not MEDLINE
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      – TitleFull: Physicochemical and Proteolytic Barriers Limiting Activity of Cpl-1 and Pal Endolysins in Human Circulation.
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