A Cryptic Pocket Allosterically Modulates Oligosaccharide Binding to DC-SIGN.
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| Title: | A Cryptic Pocket Allosterically Modulates Oligosaccharide Binding to DC-SIGN. |
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| Authors: | Lefèbre J; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria., Besch M; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria., Gamarra MD; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), Ciudad de Buenos Aires C1428EGA, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, Ciudad de Buenos Aires C1428EHA, Argentina., Kapp-Joswig JO; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany., Balke A; Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany., Aleksić S; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany., Flatau H; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria., Suchy G; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria., Georgieva E; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany., Scheerer P; Institute of Medical Physics and Biophysics, Group Structural Biology of Cellular Signaling, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany., Keller BG; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Arnimallee 22, Berlin 14195, Germany., Modenutti CP; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (FCEyN-UBA), Ciudad de Buenos Aires C1428EGA, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Pabellón 2 de Ciudad Universitaria, Ciudad de Buenos Aires C1428EHA, Argentina.; Istituto di Biologia e Biotecnologia Agraria (IBBA), Consiglio Nazionale della Ricerca (CNR), Via Alfonso Corti nr. 12, Milano 20133, Italia., Rademacher C; Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.; Department of Microbiology, Immunology and Genetics, University of Vienna, Max F. Perutz Laboratories, Dr. Bohr Gasse 9, Vienna 1030, Austria. |
| Source: | JACS Au [JACS Au] 2026 Jan 20; Vol. 6 (2), pp. 1048-1060. Date of Electronic Publication: 2026 Jan 20 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101775714 Publication Model: eCollection Cited Medium: Internet ISSN: 2691-3704 (Electronic) Linking ISSN: 26913704 NLM ISO Abbreviation: JACS Au Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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