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Etranacogene dezaparvovec in people with hemophilia B with preexisting adeno-associated virus 5 neutralizing antibodies: 4-year subgroup results from the HOPE-B trial.

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Title: Etranacogene dezaparvovec in people with hemophilia B with preexisting adeno-associated virus 5 neutralizing antibodies: 4-year subgroup results from the HOPE-B trial.
Authors: Klamroth R; Internal Medicine, Vascular Medicine and Coagulation Disorders, Vivantes Clinic Friedrichshain, Berlin, Germany., Monahan PE; CSL Behring, King of Prussia, Pennsylvania, USA., Van der Valk P; Centre for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Quon D; Orthopedic Hemophilia Treatment Center, The Luskin Orthopedic Institute for Children, Los Angeles, California, USA., Kazmi RS; Department of Hematology, University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom., Coppens M; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension & Thrombosis, Amsterdam, The Netherlands., O'Connell N; National Coagulation Centre, Department of Hematology, St. James's Hospital, Dublin, Ireland.; School of Medicine, Trinity College, Dublin, Ireland., Pipe SW; Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, Michigan, USA., von Drygalski A; Division of Hematology/Oncology, Department of Medicine, University of California San Diego, San Diego, California, USA., Afzal S; ProtaGene CGT GmbH, Heidelberg, Germany., Gabriel R; ProtaGene CGT GmbH, Heidelberg, Germany., Youssar L; ProtaGene CGT GmbH, Heidelberg, Germany., Gill S; CSL Behring, King of Prussia, Pennsylvania, USA., Jansen N; CSL Behring, King of Prussia, Pennsylvania, USA., Wang F; CSL Behring, King of Prussia, Pennsylvania, USA., Le Quellec S; CSL Behring, King of Prussia, Pennsylvania, USA., Hermans C; Department of Internal Medicine, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Source: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2026 Jan 19; Vol. 10 (1), pp. 103360. Date of Electronic Publication: 2026 Jan 19 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101703775 Publication Model: eCollection Cited Medium: Internet ISSN: 2475-0379 (Electronic) Linking ISSN: 24750379 NLM ISO Abbreviation: Res Pract Thromb Haemost Subsets: In Process
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  Data: Etranacogene dezaparvovec in people with hemophilia B with preexisting adeno-associated virus 5 neutralizing antibodies: 4-year subgroup results from the HOPE-B trial.
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  Data: <searchLink fieldCode="AU" term="%22Klamroth+R%22">Klamroth R</searchLink>; Internal Medicine, Vascular Medicine and Coagulation Disorders, Vivantes Clinic Friedrichshain, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Monahan+PE%22">Monahan PE</searchLink>; CSL Behring, King of Prussia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Van+der+Valk+P%22">Van der Valk P</searchLink>; Centre for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Quon+D%22">Quon D</searchLink>; Orthopedic Hemophilia Treatment Center, The Luskin Orthopedic Institute for Children, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Kazmi+RS%22">Kazmi RS</searchLink>; Department of Hematology, University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Coppens+M%22">Coppens M</searchLink>; Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension & Thrombosis, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22O'Connell+N%22">O'Connell N</searchLink>; National Coagulation Centre, Department of Hematology, St. James's Hospital, Dublin, Ireland.; School of Medicine, Trinity College, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Pipe+SW%22">Pipe SW</searchLink>; Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22von+Drygalski+A%22">von Drygalski A</searchLink>; Division of Hematology/Oncology, Department of Medicine, University of California San Diego, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Afzal+S%22">Afzal S</searchLink>; ProtaGene CGT GmbH, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gabriel+R%22">Gabriel R</searchLink>; ProtaGene CGT GmbH, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Youssar+L%22">Youssar L</searchLink>; ProtaGene CGT GmbH, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gill+S%22">Gill S</searchLink>; CSL Behring, King of Prussia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Jansen+N%22">Jansen N</searchLink>; CSL Behring, King of Prussia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; CSL Behring, King of Prussia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Le+Quellec+S%22">Le Quellec S</searchLink>; CSL Behring, King of Prussia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hermans+C%22">Hermans C</searchLink>; Department of Internal Medicine, Cliniques universitaires Saint-Luc, Brussels, Belgium.
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