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Human CSF proteogenomics links genetic variation to neurodegenerative disease proteins.

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Title: Human CSF proteogenomics links genetic variation to neurodegenerative disease proteins.
Authors: Puerta R; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; Doctorate in Biotechnology, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Universitat de Barcelona, Spain., García-González P; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Doctorate in Biotechnology, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Universitat de Barcelona, Spain., de Rojas I; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxemburg.; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Capdevila-Bayo M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Barcelona, Spain., Olivé C; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; Doctorate in Biotechnology, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Universitat de Barcelona, Spain., Muñoz-Morales Á; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; Doctorate in Biotechnology, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Universitat de Barcelona, Spain., Bayón-Buján P; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Valenzuela A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Yang C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Timsina J; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Liu M; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA., Chakkarai S; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA., Sotolongo-Grau O; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Calm B; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Miguel A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Solivar A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Montrreal L; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Martínez M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Khan A; Johnson & Johnson, Neuroscience Discovery., Zhao F; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA., Tantinyà N; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Rosende-Roca M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Alegret M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Moreno-Grau S; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Fernández MV; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Marquié M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Valero S; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Cavazos JE; South Texas Alzheimer's Disease Research Center, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA., Sanz P; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Montalban X; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology and Multiple Sclerosis Center of Catalonia (Cemcat), Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Tàrraga L; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Smets B; Johnson & Johnson, Neuroscience Discovery., Boada M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Seshadri S; National Heart, Lung, and Blood Institute's Framingham Heart Study; Framingham, Massachusetts 01702, United States.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine; Boston, Massachusetts 02118, United States.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA., Sargurupremraj M; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Cano A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Cabrera-Socorro A; Johnson & Johnson, Neuroscience Discovery., Ruiz A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.; Department of Microbiology, Immunology and Molecular Genetics. Long School of Medicine. University of Texas Health Science Center, San Antonio, Texas, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Feb 22. Date of Electronic Publication: 2026 Feb 22.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Human CSF proteogenomics links genetic variation to neurodegenerative disease proteins.
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  Data: <searchLink fieldCode="AU" term="%22Puerta+R%22">Puerta R</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; Doctorate in Biotechnology, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Universitat de Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22García-González+P%22">García-González P</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Doctorate in Biotechnology, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. 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Diagonal 643, 08028 Barcelona, Universitat de Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Muñoz-Morales+Á%22">Muñoz-Morales Á</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; Doctorate in Biotechnology, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Universitat de Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bayón-Buján+P%22">Bayón-Buján P</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Valenzuela+A%22">Valenzuela A</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Timsina+J%22">Timsina J</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Chakkarai+S%22">Chakkarai S</searchLink>; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Sotolongo-Grau+O%22">Sotolongo-Grau O</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Calm+B%22">Calm B</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Miguel+A%22">Miguel A</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Solivar+A%22">Solivar A</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Montrreal+L%22">Montrreal L</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez+M%22">Martínez M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Johnson & Johnson, Neuroscience Discovery.<br /><searchLink fieldCode="AU" term="%22Zhao+F%22">Zhao F</searchLink>; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tantinyà+N%22">Tantinyà N</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Rosende-Roca+M%22">Rosende-Roca M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Alegret+M%22">Alegret M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Moreno-Grau+S%22">Moreno-Grau S</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández+MV%22">Fernández MV</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Marquié+M%22">Marquié M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Valero+S%22">Valero S</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; 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Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Smets+B%22">Smets B</searchLink>; Johnson & Johnson, Neuroscience Discovery.<br /><searchLink fieldCode="AU" term="%22Boada+M%22">Boada M</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Seshadri+S%22">Seshadri S</searchLink>; National Heart, Lung, and Blood Institute's Framingham Heart Study; Framingham, Massachusetts 01702, United States.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine; Boston, Massachusetts 02118, United States.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Sargurupremraj+M%22">Sargurupremraj M</searchLink>; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Cano+A%22">Cano A</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cabrera-Socorro+A%22">Cabrera-Socorro A</searchLink>; Johnson & Johnson, Neuroscience Discovery.<br /><searchLink fieldCode="AU" term="%22Ruiz+A%22">Ruiz A</searchLink>; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.; Department of Microbiology, Immunology and Molecular Genetics. Long School of Medicine. University of Texas Health Science Center, San Antonio, Texas, USA.
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