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Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages.

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Title: Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages.
Authors: Russell CD; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK.; Baillie-Gifford Pandemic Science Hub, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK., Marshall J; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK., McHugh BJ; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK., Michno BJ; Department of Evolutionary Immunology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Kraków 31-007, Poland.; Doctoral School of Exact and Natural Sciences, Jagiellonian University, Kraków 31-007, Poland., Cholewa-Waclaw J; High Content Screening Facility, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK., Yebra G; Roslin Institute, The University of Edinburgh, Midlothian EH25 9RG, UK., Chepsat J; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK., Jones GR; School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK., McHugh MP; Department of Clinical Microbiology, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.; School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK., Lynskey NN; Roslin Institute, The University of Edinburgh, Midlothian EH25 9RG, UK., Renshaw SA; Florey Institute, Bateson Centre and Division of Clinical Medicine, School of Medicine and Population Health, Sheffield S10 2RX, UK., Prajsnar TK; Department of Evolutionary Immunology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Kraków 31-007, Poland., Baillie JK; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK.; Baillie-Gifford Pandemic Science Hub, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.; Roslin Institute, The University of Edinburgh, Midlothian EH25 9RG, UK., Fitzgerald JR; Roslin Institute, The University of Edinburgh, Midlothian EH25 9RG, UK., Dockrell DH; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK.
Source: Science advances [Sci Adv] 2026 Feb 27; Vol. 12 (9), pp. eaea0375. Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages.
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  Data: <searchLink fieldCode="AU" term="%22Russell+CD%22">Russell CD</searchLink>; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK.; Baillie-Gifford Pandemic Science Hub, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22Marshall+J%22">Marshall J</searchLink>; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22McHugh+BJ%22">McHugh BJ</searchLink>; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22Michno+BJ%22">Michno BJ</searchLink>; Department of Evolutionary Immunology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Kraków 31-007, Poland.; Doctoral School of Exact and Natural Sciences, Jagiellonian University, Kraków 31-007, Poland.<br /><searchLink fieldCode="AU" term="%22Cholewa-Waclaw+J%22">Cholewa-Waclaw J</searchLink>; High Content Screening Facility, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22Yebra+G%22">Yebra G</searchLink>; Roslin Institute, The University of Edinburgh, Midlothian EH25 9RG, UK.<br /><searchLink fieldCode="AU" term="%22Chepsat+J%22">Chepsat J</searchLink>; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK.<br /><searchLink fieldCode="AU" term="%22Jones+GR%22">Jones GR</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, UK.<br /><searchLink fieldCode="AU" term="%22McHugh+MP%22">McHugh MP</searchLink>; Department of Clinical Microbiology, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.; School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK.<br /><searchLink fieldCode="AU" term="%22Lynskey+NN%22">Lynskey NN</searchLink>; Roslin Institute, The University of Edinburgh, Midlothian EH25 9RG, UK.<br /><searchLink fieldCode="AU" term="%22Renshaw+SA%22">Renshaw SA</searchLink>; Florey Institute, Bateson Centre and Division of Clinical Medicine, School of Medicine and Population Health, Sheffield S10 2RX, UK.<br /><searchLink fieldCode="AU" term="%22Prajsnar+TK%22">Prajsnar TK</searchLink>; Department of Evolutionary Immunology, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Kraków 31-007, Poland.<br /><searchLink fieldCode="AU" term="%22Baillie+JK%22">Baillie JK</searchLink>; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK.; Baillie-Gifford Pandemic Science Hub, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.; Roslin Institute, The University of Edinburgh, Midlothian EH25 9RG, UK.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+JR%22">Fitzgerald JR</searchLink>; Roslin Institute, The University of Edinburgh, Midlothian EH25 9RG, UK.<br /><searchLink fieldCode="AU" term="%22Dockrell+DH%22">Dockrell DH</searchLink>; University of Edinburgh Centre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh EH16 4UU, UK.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 Feb 27; Vol. 12 (9), pp. eaea0375. <i>Date of Electronic Publication: </i>2026 Feb 27.
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              Text: 2026 Feb 27
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