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Dual-action mitochondria-targeted prodrugs that both deplete mitochondrial glutathione and deliver a toxic payload to the matrix.

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Title: Dual-action mitochondria-targeted prodrugs that both deplete mitochondrial glutathione and deliver a toxic payload to the matrix.
Authors: Cardwell PA; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Casey AM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Chowdhury SR; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Marques E; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Yu CS; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Taig RL; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK., Caldwell ST; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK., Prudent J; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK; Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK. Electronic address: mpm37@cam.ac.uk., Hartley RC; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK. Electronic address: richard.hartley@glasgow.ac.uk.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Apr 15; Vol. 308, pp. 118706. Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dual-action mitochondria-targeted prodrugs that both deplete mitochondrial glutathione and deliver a toxic payload to the matrix.
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  Data: <searchLink fieldCode="AU" term="%22Cardwell+PA%22">Cardwell PA</searchLink>; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Casey+AM%22">Casey AM</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Chowdhury+SR%22">Chowdhury SR</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Marques+E%22">Marques E</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Yu+CS%22">Yu CS</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Taig+RL%22">Taig RL</searchLink>; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK.<br /><searchLink fieldCode="AU" term="%22Caldwell+ST%22">Caldwell ST</searchLink>; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK.<br /><searchLink fieldCode="AU" term="%22Prudent+J%22">Prudent J</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Murphy+MP%22">Murphy MP</searchLink>; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK; Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK. Electronic address: mpm37@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Hartley+RC%22">Hartley RC</searchLink>; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK. Electronic address: richard.hartley@glasgow.ac.uk.
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              Text: 2026 Apr 15
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