Dual-action mitochondria-targeted prodrugs that both deplete mitochondrial glutathione and deliver a toxic payload to the matrix.
Saved in:
| Title: | Dual-action mitochondria-targeted prodrugs that both deplete mitochondrial glutathione and deliver a toxic payload to the matrix. |
|---|---|
| Authors: | Cardwell PA; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Casey AM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Chowdhury SR; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Marques E; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Yu CS; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Taig RL; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK., Caldwell ST; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK., Prudent J; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK; Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK. Electronic address: mpm37@cam.ac.uk., Hartley RC; School of Chemistry, Joseph Black Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK. Electronic address: richard.hartley@glasgow.ac.uk. |
| Source: | European journal of medicinal chemistry [Eur J Med Chem] 2026 Apr 15; Vol. 308, pp. 118706. Date of Electronic Publication: 2026 Feb 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
Be the first to leave a comment!
