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HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization.

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Title: HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization.
Authors: Htet M; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA., Estay-Olmos C; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA., Hu L; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Wu Y; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Powers BE; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA., Campbell CD; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA., Rameshwar A; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA., Ahmed MR; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Center for Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wang Y; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA., Menon V; Center for Translational & Computational Neuroimmunology, Department of Neurology, and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., De Jager PL; Center for Translational & Computational Neuroimmunology, Department of Neurology, and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA., Kaas GA; Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Colbran RJ; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Greer CB; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA. Electronic address: cgreer@luc.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Apr; Vol. 302 (4), pp. 111325. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization.
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  Data: <searchLink fieldCode="AU" term="%22Htet+M%22">Htet M</searchLink>; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Estay-Olmos+C%22">Estay-Olmos C</searchLink>; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Hu+L%22">Hu L</searchLink>; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Powers+BE%22">Powers BE</searchLink>; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Campbell+CD%22">Campbell CD</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Rameshwar+A%22">Rameshwar A</searchLink>; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Ahmed+MR%22">Ahmed MR</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Hohman+TJ%22">Hohman TJ</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Center for Human Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Schneider+JA%22">Schneider JA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Menon+V%22">Menon V</searchLink>; Center for Translational & Computational Neuroimmunology, Department of Neurology, and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Center for Translational & Computational Neuroimmunology, Department of Neurology, and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Kaas+GA%22">Kaas GA</searchLink>; Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Colbran+RJ%22">Colbran RJ</searchLink>; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Greer+CB%22">Greer CB</searchLink>; Molecular Pharmacology and Neuroscience, Loyola University Chicago Health Science Center, Maywood, Illinois, USA. Electronic address: cgreer@luc.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2026 Apr; Vol. 302 (4), pp. 111325. <i>Date of Electronic Publication: </i>2026 Feb 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2026.111325
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        Text: English
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        StartPage: 111325
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      – TitleFull: HEXIM1/P-TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization.
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