APECx-Anaesthesia, Perfusion and Surgical Practices in Cardiac Surgery: Main Study Protocol of a Modular Multiphase Prospective International Multicentre Observational Study.

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Title: APECx-Anaesthesia, Perfusion and Surgical Practices in Cardiac Surgery: Main Study Protocol of a Modular Multiphase Prospective International Multicentre Observational Study.
Authors: Seegers JC; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Grewal N; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Aortic Institute at Yale New-Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA., van Vliet R; Department of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Berger T; Department of Cardiovascular Surgery, University Heart Center Freiburg, University Medical Center Freiburg, Freiburg, Germany.; Faculty of Medicine, Albert Ludwigs University Freiburg, Freiburg, Germany., Bhatia B; Department of Anaesthesia and Perioperative Medicine, Victorian Heart Hospital, Monash Health, Clayton, Australia., Cozowicz C; Department of Anesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, Salzburg, Austria., Czerny M; Department of Cardiovascular Surgery, University Heart Center Freiburg, University Medical Center Freiburg, Freiburg, Germany.; Faculty of Medicine, Albert Ludwigs University Freiburg, Freiburg, Germany., D'Andria Ursoleo J; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Corte AD; Department of Cardiac Surgery, V. Monaldi Hospital, Naples, Italy.; Department of Translational Medical Sciences, University of Campania 'L. Vanvitelli', Naples, Italy., Dodic S; Department of Anaesthesia & Pain Management, the Royal Melbourne Hospital, Melbourne, Australia., Fanning JP; Anaesthesia and Perfusion Services, the Prince Charles Hospital, Brisbane, Australia.; School of Medicine, The University of Queensland, Brisbane, Australia., Gasteiger L; Department of Anesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck, Austria., Grewal S; Department of Orthopaedic Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands., Grønlykke L; Department of Cardiothoracic Anaesthesiology, Copenhagen University Hospital-Righospitalet, Copenhagen, Denmark., Huhn R; Department of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Anesthesiology, Kerckhoff-Klinik GmbH Bad Nauheim, Justus Liebig University Giessen, Bad Nauheim, Germany., Idhrees M; Department of Cardiothoracic Surgery, Saraswati Institute of Medical Sciences (SIMS) Hospital, Chennai, India., Itenov TS; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Jassar AS; Division of Cardiac Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ju JW; Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University, Seoul, South Korea., Karalapillai D; Department of Intensive Care, Austin Hospital, Melbourne, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Australia., Kunst G; Department of Anaesthetics and Pain Medicine, King's College Hospital NHS Foundation Trust, London, UK.; School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre of Excellence, London, UK., Lannemyr L; Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden., Lin DY; Department of Anesthesiology and Pain Medicine, Flinders Medical Centre, Adelaide, Australia.; College of Medicine and Public Health, Flinders University, Adelaide, Australia., Mariani C; Division of Cardiac Surgery, IRCCS Azienda Ospedaliero, University of Bologna, Bologna, Italy.; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy., Martinsson A; Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden., McCabe E; Department of Anaesthesia and Perioperative Medicine, Victorian Heart Hospital, Monash Health, Clayton, Australia.; Victorian Cardiac Anaesthesia Laboratory, Victorian Heart Institute, Monash University, Clayton, Australia., Milne B; Department of Anaesthetics and Pain Medicine, King's College Hospital NHS Foundation Trust, London, UK., Monaco F; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.; Cadiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Azienda Ospedaliero, Universitaria Sant'orsola, Bologna, Italy., Møller-Sørensen PH; Department of Cardiothoracic Anaesthesiology, Copenhagen University Hospital-Righospitalet, Copenhagen, Denmark., Neuner M; Department of Anesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, Salzburg, Austria., Pacini D; Division of Cardiac Surgery, IRCCS Azienda Ospedaliero, University of Bologna, Bologna, Italy.; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy., Perry LA; Department of Anaesthesia and Perioperative Medicine, Victorian Heart Hospital, Monash Health, Clayton, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Australia.; Victorian Cardiac Anaesthesia Laboratory, Victorian Heart Institute, Monash University, Clayton, Australia., Raman J; Department of Cardiothoracic Surgery, Townsville University Hospital, Townsville, Australia., Schmidt AF; Department of Cardiology, Academic Medical Center, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Institute of Cardiovascular Science, University College London, London, UK., Schoenhoff F; Department of Cardiac Surgery, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland., Segal R; Department of Anaesthesia & Pain Management, the Royal Melbourne Hospital, Melbourne, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia., Neto AS; Department of Intensive Care, Austin Hospital, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paolo, Brazil., Shook DC; Department of Anesthesiology, Birgham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Torregroza C; Department of Anesthesiology, Kerckhoff-Klinik GmbH Bad Nauheim, Justus Liebig University Giessen, Bad Nauheim, Germany., Vives M; Department of Anestesia & Critical Care, Clínica Universidad de Navarra, Pamplona, Spain., Zochios V; Department of Cardiothoracic Critical Care Medicine and ECMO Unit, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., van Meenen DMP; Department of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Beukers AM; Department of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Source: Acta anaesthesiologica Scandinavica [Acta Anaesthesiol Scand] 2026 Apr; Vol. 70 (4), pp. e70214.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0370270 Publication Model: Print Cited Medium: Internet ISSN: 1399-6576 (Electronic) Linking ISSN: 00015172 NLM ISO Abbreviation: Acta Anaesthesiol Scand Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: APECx-Anaesthesia, Perfusion and Surgical Practices in Cardiac Surgery: Main Study Protocol of a Modular Multiphase Prospective International Multicentre Observational Study.
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  Data: <searchLink fieldCode="AU" term="%22Seegers+JC%22">Seegers JC</searchLink>; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Grewal+N%22">Grewal N</searchLink>; Department of Cardiothoracic Surgery, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Aortic Institute at Yale New-Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22van+Vliet+R%22">van Vliet R</searchLink>; Department of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Berger+T%22">Berger T</searchLink>; Department of Cardiovascular Surgery, University Heart Center Freiburg, University Medical Center Freiburg, Freiburg, Germany.; Faculty of Medicine, Albert Ludwigs University Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bhatia+B%22">Bhatia B</searchLink>; Department of Anaesthesia and Perioperative Medicine, Victorian Heart Hospital, Monash Health, Clayton, Australia.<br /><searchLink fieldCode="AU" term="%22Cozowicz+C%22">Cozowicz C</searchLink>; Department of Anesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, Salzburg, Austria.<br /><searchLink fieldCode="AU" term="%22Czerny+M%22">Czerny M</searchLink>; Department of Cardiovascular Surgery, University Heart Center Freiburg, University Medical Center Freiburg, Freiburg, Germany.; Faculty of Medicine, Albert Ludwigs University Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22D'Andria+Ursoleo+J%22">D'Andria Ursoleo J</searchLink>; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Corte+AD%22">Corte AD</searchLink>; Department of Cardiac Surgery, V. Monaldi Hospital, Naples, Italy.; Department of Translational Medical Sciences, University of Campania 'L. Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Dodic+S%22">Dodic S</searchLink>; Department of Anaesthesia & Pain Management, the Royal Melbourne Hospital, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Fanning+JP%22">Fanning JP</searchLink>; Anaesthesia and Perfusion Services, the Prince Charles Hospital, Brisbane, Australia.; School of Medicine, The University of Queensland, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Gasteiger+L%22">Gasteiger L</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Grewal+S%22">Grewal S</searchLink>; Department of Orthopaedic Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Grønlykke+L%22">Grønlykke L</searchLink>; Department of Cardiothoracic Anaesthesiology, Copenhagen University Hospital-Righospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Huhn+R%22">Huhn R</searchLink>; Department of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Anesthesiology, Kerckhoff-Klinik GmbH Bad Nauheim, Justus Liebig University Giessen, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Idhrees+M%22">Idhrees M</searchLink>; Department of Cardiothoracic Surgery, Saraswati Institute of Medical Sciences (SIMS) Hospital, Chennai, India.<br /><searchLink fieldCode="AU" term="%22Itenov+TS%22">Itenov TS</searchLink>; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jassar+AS%22">Jassar AS</searchLink>; Division of Cardiac Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ju+JW%22">Ju JW</searchLink>; Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Karalapillai+D%22">Karalapillai D</searchLink>; Department of Intensive Care, Austin Hospital, Melbourne, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Kunst+G%22">Kunst G</searchLink>; Department of Anaesthetics and Pain Medicine, King's College Hospital NHS Foundation Trust, London, UK.; School of Cardiovascular Medicine & Sciences, King's College London British Heart Foundation Centre of Excellence, London, UK.<br /><searchLink fieldCode="AU" term="%22Lannemyr+L%22">Lannemyr L</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Lin+DY%22">Lin DY</searchLink>; Department of Anesthesiology and Pain Medicine, Flinders Medical Centre, Adelaide, Australia.; College of Medicine and Public Health, Flinders University, Adelaide, Australia.<br /><searchLink fieldCode="AU" term="%22Mariani+C%22">Mariani C</searchLink>; Division of Cardiac Surgery, IRCCS Azienda Ospedaliero, University of Bologna, Bologna, Italy.; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Martinsson+A%22">Martinsson A</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22McCabe+E%22">McCabe E</searchLink>; Department of Anaesthesia and Perioperative Medicine, Victorian Heart Hospital, Monash Health, Clayton, Australia.; Victorian Cardiac Anaesthesia Laboratory, Victorian Heart Institute, Monash University, Clayton, Australia.<br /><searchLink fieldCode="AU" term="%22Milne+B%22">Milne B</searchLink>; Department of Anaesthetics and Pain Medicine, King's College Hospital NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Monaco+F%22">Monaco F</searchLink>; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.; Cadiothoracic and Vascular Anesthesia and Intensive Care, IRCCS Azienda Ospedaliero, Universitaria Sant'orsola, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Møller-Sørensen+PH%22">Møller-Sørensen PH</searchLink>; Department of Cardiothoracic Anaesthesiology, Copenhagen University Hospital-Righospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Neuner+M%22">Neuner M</searchLink>; Department of Anesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, Salzburg, Austria.<br /><searchLink fieldCode="AU" term="%22Pacini+D%22">Pacini D</searchLink>; Division of Cardiac Surgery, IRCCS Azienda Ospedaliero, University of Bologna, Bologna, Italy.; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Perry+LA%22">Perry LA</searchLink>; Department of Anaesthesia and Perioperative Medicine, Victorian Heart Hospital, Monash Health, Clayton, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Australia.; Victorian Cardiac Anaesthesia Laboratory, Victorian Heart Institute, Monash University, Clayton, Australia.<br /><searchLink fieldCode="AU" term="%22Raman+J%22">Raman J</searchLink>; Department of Cardiothoracic Surgery, Townsville University Hospital, Townsville, Australia.<br /><searchLink fieldCode="AU" term="%22Schmidt+AF%22">Schmidt AF</searchLink>; Department of Cardiology, Academic Medical Center, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Institute of Cardiovascular Science, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Schoenhoff+F%22">Schoenhoff F</searchLink>; Department of Cardiac Surgery, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Segal+R%22">Segal R</searchLink>; Department of Anaesthesia & Pain Management, the Royal Melbourne Hospital, Melbourne, Australia.; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Neto+AS%22">Neto AS</searchLink>; Department of Intensive Care, Austin Hospital, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paolo, Brazil.<br /><searchLink fieldCode="AU" term="%22Shook+DC%22">Shook DC</searchLink>; Department of Anesthesiology, Birgham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Torregroza+C%22">Torregroza C</searchLink>; Department of Anesthesiology, Kerckhoff-Klinik GmbH Bad Nauheim, Justus Liebig University Giessen, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Vives+M%22">Vives M</searchLink>; Department of Anestesia & Critical Care, Clínica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Zochios+V%22">Zochios V</searchLink>; Department of Cardiothoracic Critical Care Medicine and ECMO Unit, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22van+Meenen+DMP%22">van Meenen DMP</searchLink>; Department of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.; Department of Intensive Care, Amsterdam University Medical Centers, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Beukers+AM%22">Beukers AM</searchLink>; Department of Anesthesiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
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