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NR2F6 deletion revives CAR-T cell function and induces antigen-agnostic immune memory in solid tumors.

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Title: NR2F6 deletion revives CAR-T cell function and induces antigen-agnostic immune memory in solid tumors.
Authors: Humer D; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Klepsch V; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria. victoria.klepsch@i-med.ac.at., Rieder D; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria., Hölzl I; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Schreiber D; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Lang V; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Koutník J; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Peer S; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck and Tyrolean Cancer Research Institute, Medical University of Innsbruck, Innsbruck, Austria., Sajinovic T; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Wille V; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Fürst A; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany., Savic D; Tyrolean Cancer Research Institute, Innsbruck, Austria.; Department of Therapeutic Radiology and Oncology, Medical University Innsbruck, Innsbruck, Austria., Diem G; Institute of Hygiene and Medical Microbiology Medical University of Innsbruck, Innsbruck, Austria., Posch W; Institute of Hygiene and Medical Microbiology Medical University of Innsbruck, Innsbruck, Austria., Skvortsova II; Tyrolean Cancer Research Institute, Innsbruck, Austria.; Department of Therapeutic Radiology and Oncology, Medical University Innsbruck, Innsbruck, Austria., Krogsdam A; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria., Sopper S; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck and Tyrolean Cancer Research Institute, Medical University of Innsbruck, Innsbruck, Austria., Kobold S; Institute for Clinical Pharmacology, Klinikum der Universität München, Munich, Germany.; German Cancer Consortium, a partnership between LMU Hospital and the DKFZ, Munich, Germany., Trajanoski Z; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria., Siegmund K; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Thuille N; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Gruber T; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria., Wolf D; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck and Tyrolean Cancer Research Institute, Medical University of Innsbruck, Innsbruck, Austria., Baier G; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria. gottfried.baier@i-med.ac.at.
Source: Nature communications [Nat Commun] 2026 Feb 27; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Humer+D%22">Humer D</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Klepsch+V%22">Klepsch V</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria. victoria.klepsch@i-med.ac.at.<br /><searchLink fieldCode="AU" term="%22Rieder+D%22">Rieder D</searchLink>; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Hölzl+I%22">Hölzl I</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Schreiber+D%22">Schreiber D</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Lang+V%22">Lang V</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Koutník+J%22">Koutník J</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Peer+S%22">Peer S</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck and Tyrolean Cancer Research Institute, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Sajinovic+T%22">Sajinovic T</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Wille+V%22">Wille V</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Fürst+A%22">Fürst A</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Savic+D%22">Savic D</searchLink>; Tyrolean Cancer Research Institute, Innsbruck, Austria.; Department of Therapeutic Radiology and Oncology, Medical University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Diem+G%22">Diem G</searchLink>; Institute of Hygiene and Medical Microbiology Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Posch+W%22">Posch W</searchLink>; Institute of Hygiene and Medical Microbiology Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Skvortsova+II%22">Skvortsova II</searchLink>; Tyrolean Cancer Research Institute, Innsbruck, Austria.; Department of Therapeutic Radiology and Oncology, Medical University Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Krogsdam+A%22">Krogsdam A</searchLink>; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Sopper+S%22">Sopper S</searchLink>; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck and Tyrolean Cancer Research Institute, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Kobold+S%22">Kobold S</searchLink>; Institute for Clinical Pharmacology, Klinikum der Universität München, Munich, Germany.; German Cancer Consortium, a partnership between LMU Hospital and the DKFZ, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Trajanoski+Z%22">Trajanoski Z</searchLink>; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Siegmund+K%22">Siegmund K</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Thuille+N%22">Thuille N</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Gruber+T%22">Gruber T</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Wolf+D%22">Wolf D</searchLink>; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck and Tyrolean Cancer Research Institute, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Baier+G%22">Baier G</searchLink>; Institute for Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria. gottfried.baier@i-med.ac.at.
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