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A potential therapeutic effect of 84-B10 in MASLD through promotion of FASN degradation.

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Title: A potential therapeutic effect of 84-B10 in MASLD through promotion of FASN degradation.
Authors: Bai YP; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Yin Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China., Wang SM; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Chen JM; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China., Zhang ZH; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Zhu ZQ; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China.; School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China., Shao GX; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Zhu Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China., Jiang YY; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. yyjiang@ustc.edu.cn.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China. yyjiang@ustc.edu.cn.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China. yyjiang@ustc.edu.cn., Sun BC; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. sunbc@ahmu.edu.cn.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China. sunbc@ahmu.edu.cn.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China. sunbc@ahmu.edu.cn., Xu DQ; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.; School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jul; Vol. 47 (7), pp. 1840-1855. Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A potential therapeutic effect of 84-B10 in MASLD through promotion of FASN degradation.
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  Data: <searchLink fieldCode="AU" term="%22Bai+YP%22">Bai YP</searchLink>; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Yin+Y%22">Yin Y</searchLink>; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Wang+SM%22">Wang SM</searchLink>; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Chen+JM%22">Chen JM</searchLink>; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Zhang+ZH%22">Zhang ZH</searchLink>; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Zhu+ZQ%22">Zhu ZQ</searchLink>; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China.; School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Shao+GX%22">Shao GX</searchLink>; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China.<br /><searchLink fieldCode="AU" term="%22Jiang+YY%22">Jiang YY</searchLink>; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. yyjiang@ustc.edu.cn.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China. yyjiang@ustc.edu.cn.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China. yyjiang@ustc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sun+BC%22">Sun BC</searchLink>; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. sunbc@ahmu.edu.cn.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China. sunbc@ahmu.edu.cn.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China. sunbc@ahmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xu+DQ%22">Xu DQ</searchLink>; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.; MOE Innovation Center for Basic Research in Tumor Immunotherapy, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.; Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.; School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China. xudengqiu@fy.ahmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2026 Jul; Vol. 47 (7), pp. 1840-1855. <i>Date of Electronic Publication: </i>2026 Feb 27.
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        Value: 10.1038/s41401-025-01745-x
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        Text: English
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        StartPage: 1840
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              Text: 2026 Jul
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