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Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial.

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Title: Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial.
Authors: Nicholls SJ; Victorian Heart Institute, Monash University, Clayton, Victoria, Australia. stephen.nicholls@monash.edu., Nelson AJ; Victorian Heart Institute, Monash University, Clayton, Victoria, Australia., Ditmarsch M; NewAmsterdam Pharma, Amsterdam, the Netherlands., Kastelein JJP; NewAmsterdam Pharma, Amsterdam, the Netherlands.; Department of Vascular Medicine, University of Amsterdam, Amsterdam, the Netherlands., Ballantyne CM; Baylor College of Medicine, Houston, TX, USA., Ray KK; Imperial College London, London, UK., Navar AM; UT Southwestern, Dallas, TX, USA., Nissen SE; Cleveland Clinic, Cleveland, OH, USA., Goldberg AC; Washington University School of Medicine, St Louis, MO, USA., Brunham LR; Department of Medicine and Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada., Wuerdeman E; NewAmsterdam Pharma, Amsterdam, the Netherlands., Neild AL; NewAmsterdam Pharma, Amsterdam, the Netherlands., Kling D; NewAmsterdam Pharma, Amsterdam, the Netherlands., Hsieh A; NewAmsterdam Pharma, Amsterdam, the Netherlands., Butters J; Victorian Heart Institute, Monash University, Clayton, Victoria, Australia., Ference BA; Centre for Naturally Randomized Trials, University of Cambridge, Cambridge, UK., Laufs U; Klinik und Poliklinik für Kardiologie, Leipzig University, Leipzig, Germany., Banach M; Medical University of Lodz, Lodz, Poland.; The John Paul II Catholic University of Lublin, Lublin, Poland., Mehran R; Mt Sinai School of Medicine, New York, NY, USA., Catapano AL; University of Milan and Multimedica IRCCS, Milan, Italy., Szarek M; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; State University of New York Downstate School of Public Health, Brooklyn, NY, USA., Balinskaite V; Medpace, Cincinnati, OH, USA., Davidson MH; NewAmsterdam Pharma, Amsterdam, the Netherlands.
Source: Nature medicine [Nat Med] 2026 Mar; Vol. 32 (3), pp. 1052-1060. Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Nicholls+SJ%22">Nicholls SJ</searchLink>; Victorian Heart Institute, Monash University, Clayton, Victoria, Australia. stephen.nicholls@monash.edu.<br /><searchLink fieldCode="AU" term="%22Nelson+AJ%22">Nelson AJ</searchLink>; Victorian Heart Institute, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ditmarsch+M%22">Ditmarsch M</searchLink>; NewAmsterdam Pharma, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kastelein+JJP%22">Kastelein JJP</searchLink>; NewAmsterdam Pharma, Amsterdam, the Netherlands.; Department of Vascular Medicine, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ballantyne+CM%22">Ballantyne CM</searchLink>; Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ray+KK%22">Ray KK</searchLink>; Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Navar+AM%22">Navar AM</searchLink>; UT Southwestern, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Nissen+SE%22">Nissen SE</searchLink>; Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Goldberg+AC%22">Goldberg AC</searchLink>; Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Brunham+LR%22">Brunham LR</searchLink>; Department of Medicine and Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Wuerdeman+E%22">Wuerdeman E</searchLink>; NewAmsterdam Pharma, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Neild+AL%22">Neild AL</searchLink>; NewAmsterdam Pharma, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kling+D%22">Kling D</searchLink>; NewAmsterdam Pharma, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hsieh+A%22">Hsieh A</searchLink>; NewAmsterdam Pharma, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Butters+J%22">Butters J</searchLink>; Victorian Heart Institute, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ference+BA%22">Ference BA</searchLink>; Centre for Naturally Randomized Trials, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Laufs+U%22">Laufs U</searchLink>; Klinik und Poliklinik für Kardiologie, Leipzig University, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Banach+M%22">Banach M</searchLink>; Medical University of Lodz, Lodz, Poland.; The John Paul II Catholic University of Lublin, Lublin, Poland.<br /><searchLink fieldCode="AU" term="%22Mehran+R%22">Mehran R</searchLink>; Mt Sinai School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Catapano+AL%22">Catapano AL</searchLink>; University of Milan and Multimedica IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Szarek+M%22">Szarek M</searchLink>; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; State University of New York Downstate School of Public Health, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Balinskaite+V%22">Balinskaite V</searchLink>; Medpace, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+MH%22">Davidson MH</searchLink>; NewAmsterdam Pharma, Amsterdam, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 Mar; Vol. 32 (3), pp. 1052-1060. <i>Date of Electronic Publication: </i>2026 Feb 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Company%22">Nature Publishing Company </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502015 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-170X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210788956%22">10788956 </searchLink><i>NLM ISO Abbreviation: </i>Nat Med <i>Subsets: </i>MEDLINE
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