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Risk of Breast Cancer After Ovarian Cancer in Women With a Pathogenic/Likely Pathogenic Variant in BRCA1 or BRCA2.

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Title: Risk of Breast Cancer After Ovarian Cancer in Women With a Pathogenic/Likely Pathogenic Variant in BRCA1 or BRCA2.
Authors: Apostol AI; Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.; Women's College Research Institute, University of Toronto, Toronto, ON, Canada., Gronwald J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Cybulski C; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Kim RH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Møller P; Department of Tumour Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Research Unit NEON-S, Faculty of Medicine and Health Technology, Tampere University and TAYS Cancer Centre, Tampere, Finland., Karlan BY; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA., Bordeleau L; Department of Oncology, Juravinski Cancer Centre and McMaster University, Hamilton, ON, Canada., Schrader I; Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, BC, Canada., Ramón Y Cajal T; Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Pal T; Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN., Eisen A; Department of Medical Oncology, Sunnybrook Odette Cancer Center, University of Toronto, Toronto, ON, Canada., Singer CF; Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Couch FJ; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN., Zakalik D; Cancer Genetics Program, Beaumont Hospital, Royal Oak, MI., Metcalfe K; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada., Olopade O; Department of Medicine and Human Genetics, University of Chicago, Chicago, IL., Tung N; Beth Israel Deaconess Medical Center, Boston, MA., Fruscio R; Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.; UO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Foulkes WD; Department of Oncology, McGill Program in Cancer Genetics, McGill University, Montreal, QC, Canada., Aeilts A; Division of Human Genetics, The Ohio State University Medical Center, Comprehensive Cancer Center, Columbus, OH., Sun P; Women's College Research Institute, University of Toronto, Toronto, ON, Canada., Lubinski J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland., Narod SA; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Kotsopoulos J; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Corporate Authors: Hereditary Breast Cancer Clinical Study Group
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2026 Apr; Vol. 44 (10), pp. 883-892. Date of Electronic Publication: 2026 Feb 28.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
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  Data: Risk of Breast Cancer After Ovarian Cancer in Women With a Pathogenic/Likely Pathogenic Variant in BRCA1 or BRCA2.
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  Data: <searchLink fieldCode="AU" term="%22Apostol+AI%22">Apostol AI</searchLink>; Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Gronwald+J%22">Gronwald J</searchLink>; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Cybulski+C%22">Cybulski C</searchLink>; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Kim+RH%22">Kim RH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Møller+P%22">Møller P</searchLink>; Department of Tumour Biology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Research Unit NEON-S, Faculty of Medicine and Health Technology, Tampere University and TAYS Cancer Centre, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Karlan+BY%22">Karlan BY</searchLink>; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Bordeleau+L%22">Bordeleau L</searchLink>; Department of Oncology, Juravinski Cancer Centre and McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Schrader+I%22">Schrader I</searchLink>; Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Ramón+Y+Cajal+T%22">Ramón Y Cajal T</searchLink>; Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pal+T%22">Pal T</searchLink>; Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Eisen+A%22">Eisen A</searchLink>; Department of Medical Oncology, Sunnybrook Odette Cancer Center, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Singer+CF%22">Singer CF</searchLink>; Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Couch+FJ%22">Couch FJ</searchLink>; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Zakalik+D%22">Zakalik D</searchLink>; Cancer Genetics Program, Beaumont Hospital, Royal Oak, MI.<br /><searchLink fieldCode="AU" term="%22Metcalfe+K%22">Metcalfe K</searchLink>; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Olopade+O%22">Olopade O</searchLink>; Department of Medicine and Human Genetics, University of Chicago, Chicago, IL.<br /><searchLink fieldCode="AU" term="%22Tung+N%22">Tung N</searchLink>; Beth Israel Deaconess Medical Center, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Fruscio+R%22">Fruscio R</searchLink>; Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.; UO Gynecology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Foulkes+WD%22">Foulkes WD</searchLink>; Department of Oncology, McGill Program in Cancer Genetics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Aeilts+A%22">Aeilts A</searchLink>; Division of Human Genetics, The Ohio State University Medical Center, Comprehensive Cancer Center, Columbus, OH.<br /><searchLink fieldCode="AU" term="%22Sun+P%22">Sun P</searchLink>; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lubinski+J%22">Lubinski J</searchLink>; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.<br /><searchLink fieldCode="AU" term="%22Narod+SA%22">Narod SA</searchLink>; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kotsopoulos+J%22">Kotsopoulos J</searchLink>; Women's College Research Institute, University of Toronto, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
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