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Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation.

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Title: Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation.
Authors: Yang S; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Ge S; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Liu Z; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Chen J; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Chang F; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Shen J; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Wu F; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Sun X; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Wang Z; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Li Y; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Zhang M; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Chen R; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Feng T; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Yin T; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Fu P; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Chen M; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. mingchen301@126.com.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China. mingchen301@126.com., Yin P; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. yinpengbin@gmail.com.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China. yinpengbin@gmail.com., Hao L; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. haolibo301@sina.com.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China. haolibo301@sina.com.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Mar 01; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 01.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation.
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  Data: <searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Ge+S%22">Ge S</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chang+F%22">Chang F</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Shen+J%22">Shen J</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wu+F%22">Wu F</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+R%22">Chen R</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Feng+T%22">Feng T</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Yin+T%22">Yin T</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Fu+P%22">Fu P</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. mingchen301@126.com.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China. mingchen301@126.com.<br /><searchLink fieldCode="AU" term="%22Yin+P%22">Yin P</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. yinpengbin@gmail.com.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China. yinpengbin@gmail.com.<br /><searchLink fieldCode="AU" term="%22Hao+L%22">Hao L</searchLink>; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. haolibo301@sina.com.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China. haolibo301@sina.com.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2026 Mar 01; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Mar 01.
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