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Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation.

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Bibliographic Details
Title: Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation.
Authors: Yang S; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Ge S; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Liu Z; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Chen J; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Chang F; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Shen J; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Wu F; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Sun X; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Wang Z; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Li Y; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Zhang M; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Chen R; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Feng T; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Yin T; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Fu P; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China., Chen M; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. mingchen301@126.com.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China. mingchen301@126.com., Yin P; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. yinpengbin@gmail.com.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China. yinpengbin@gmail.com., Hao L; Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. haolibo301@sina.com.; Department of orthopedics, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxing Road, Beijing, 100853, P. R. China. haolibo301@sina.com.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Mar 01; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 01.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1477-3155
DOI:10.1186/s12951-026-04176-w