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Extensive evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host.

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Title: Extensive evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host.
Authors: Guerra-Assunção JA; HerpeslabNL, department of Viroscience, Erasmus MC, Rotterdam, the Netherlands.; Infection, Immunity and Inflammation, Institute of Child Health, University College London, London, UK., McErlean R; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Townsend K; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Cankat S; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Flaxl LM; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Tian SJ; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Turner TR; Anthony Nolan Research Institute, Royal Free Hospital, London, UK.; UCL Cancer Institute, Royal Free Campus, London, UK., Mayor NP; Anthony Nolan Research Institute, Royal Free Hospital, London, UK.; UCL Cancer Institute, Royal Free Campus, London, UK., Breuer J; Infection, Immunity and Inflammation, Institute of Child Health, University College London, London, UK.; Great Ormond Street Hospital for Children, London, UK., Swadling L; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Lowe DM; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
Source: IScience [iScience] 2026 Feb 05; Vol. 29 (3), pp. 114917. Date of Electronic Publication: 2026 Feb 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Guerra-Assunção+JA%22">Guerra-Assunção JA</searchLink>; HerpeslabNL, department of Viroscience, Erasmus MC, Rotterdam, the Netherlands.; Infection, Immunity and Inflammation, Institute of Child Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22McErlean+R%22">McErlean R</searchLink>; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Townsend+K%22">Townsend K</searchLink>; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cankat+S%22">Cankat S</searchLink>; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Flaxl+LM%22">Flaxl LM</searchLink>; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tian+SJ%22">Tian SJ</searchLink>; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Turner+TR%22">Turner TR</searchLink>; Anthony Nolan Research Institute, Royal Free Hospital, London, UK.; UCL Cancer Institute, Royal Free Campus, London, UK.<br /><searchLink fieldCode="AU" term="%22Mayor+NP%22">Mayor NP</searchLink>; Anthony Nolan Research Institute, Royal Free Hospital, London, UK.; UCL Cancer Institute, Royal Free Campus, London, UK.<br /><searchLink fieldCode="AU" term="%22Breuer+J%22">Breuer J</searchLink>; Infection, Immunity and Inflammation, Institute of Child Health, University College London, London, UK.; Great Ormond Street Hospital for Children, London, UK.<br /><searchLink fieldCode="AU" term="%22Swadling+L%22">Swadling L</searchLink>; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lowe+DM%22">Lowe DM</searchLink>; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2026 Feb 05; Vol. 29 (3), pp. 114917. <i>Date of Electronic Publication: </i>2026 Feb 05 (<i>Print Publication: </i>2026).
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