Extensive evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host.

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Title: Extensive evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host.
Authors: Guerra-Assunção JA; HerpeslabNL, department of Viroscience, Erasmus MC, Rotterdam, the Netherlands.; Infection, Immunity and Inflammation, Institute of Child Health, University College London, London, UK., McErlean R; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Townsend K; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Cankat S; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Flaxl LM; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Tian SJ; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Turner TR; Anthony Nolan Research Institute, Royal Free Hospital, London, UK.; UCL Cancer Institute, Royal Free Campus, London, UK., Mayor NP; Anthony Nolan Research Institute, Royal Free Hospital, London, UK.; UCL Cancer Institute, Royal Free Campus, London, UK., Breuer J; Infection, Immunity and Inflammation, Institute of Child Health, University College London, London, UK.; Great Ormond Street Hospital for Children, London, UK., Swadling L; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK., Lowe DM; Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.
Source: IScience [iScience] 2026 Feb 05; Vol. 29 (3), pp. 114917. Date of Electronic Publication: 2026 Feb 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2026.114917