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Targeting APE1-Redox Function Reverses SOX9-mediated Chemoresistance in Esophageal Adenocarcinoma.

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Title: Targeting APE1-Redox Function Reverses SOX9-mediated Chemoresistance in Esophageal Adenocarcinoma.
Authors: Lu H; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida. Electronic address: heng.lu@med.miami.edu., Ballout F; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida., Chen L; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida., Peng D; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida., Chen Z; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida., Soutto M; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Department of Veterans Affairs, Miami Healthcare System, Miami, Florida., Cao L; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China., Thangaretnam K; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida., Gokulan RC; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida., Wang TC; Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, New York., Que J; Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, New York., Giordano S; Department of Oncology, University of Torino and Candiolo Cancer Institute, Candiolo, Italy., Washington MK; Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee., Chen XS; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida., Sun X; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida., Ban Y; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida., McDonald OG; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, Florida., Zaika A; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Veterans Affairs, Miami Healthcare System, Miami, Florida., El-Rifai W; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Veterans Affairs, Miami Healthcare System, Miami, Florida. Electronic address: wxe45@miami.edu.
Source: Gastroenterology [Gastroenterology] 2026 Jun; Vol. 170 (7), pp. 1484-1500. Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
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  Data: Targeting APE1-Redox Function Reverses SOX9-mediated Chemoresistance in Esophageal Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Lu+H%22">Lu H</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida. Electronic address: heng.lu@med.miami.edu.<br /><searchLink fieldCode="AU" term="%22Ballout+F%22">Ballout F</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Peng+D%22">Peng D</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Soutto+M%22">Soutto M</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Department of Veterans Affairs, Miami Healthcare System, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Cao+L%22">Cao L</searchLink>; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Thangaretnam+K%22">Thangaretnam K</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Gokulan+RC%22">Gokulan RC</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Wang+TC%22">Wang TC</searchLink>; Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Que+J%22">Que J</searchLink>; Division of Digestive and Liver Diseases and Center for Human Development, Department of Medicine, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Giordano+S%22">Giordano S</searchLink>; Department of Oncology, University of Torino and Candiolo Cancer Institute, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Washington+MK%22">Washington MK</searchLink>; Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Chen+XS%22">Chen XS</searchLink>; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Ban+Y%22">Ban Y</searchLink>; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22McDonald+OG%22">McDonald OG</searchLink>; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Zaika+A%22">Zaika A</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Veterans Affairs, Miami Healthcare System, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22El-Rifai+W%22">El-Rifai W</searchLink>; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Veterans Affairs, Miami Healthcare System, Miami, Florida. Electronic address: wxe45@miami.edu.
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  Data: <searchLink fieldCode="JN" term="%220374630%22">Gastroenterology</searchLink> [Gastroenterology] 2026 Jun; Vol. 170 (7), pp. 1484-1500. <i>Date of Electronic Publication: </i>2026 Mar 02.
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      – Type: doi
        Value: 10.1053/j.gastro.2025.12.019
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        Text: English
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              Text: 2026 Jun
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