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Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification.

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Title: Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification.
Authors: Jiang Y; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China., Zheng W; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China., Xia Z; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China., Wong WW; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China., Cheng LKW; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China., Ip FC; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Hong Kong University of Science and Technology Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong 518057, China., Choi SM; Department of Medicine, Queen Elizabeth Hospital, Hospital Authority, Hong Kong Special Administrative Region, China., Chan ALT; Department of Medicine, Queen Elizabeth Hospital, Hospital Authority, Hong Kong Special Administrative Region, China., Lam CY; Department of Medicine and Geriatrics Ruttonjee & Tang Shiu Kin Hospitals, Hong Kong Special Administrative Region, China., Ho KS; Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories West Cluster, Hospital Authority, Tuen Mun, Hong Kong Special Administrative Region, China., Shum CK; Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories West Cluster, Hospital Authority, Tuen Mun, Hong Kong Special Administrative Region, China., Yuen JKY; Division of Geriatrics, Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China., Shea YF; Division of Geriatrics, Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China., Wai HM; Department of Medicine and Geriatrics, United Christian Hospital, Hospital Authority, Kwun Tong, Hong Kong Special Administrative Region, China., Mok VCT; Division of Neurology, Department of Medicine and Therapeutics, Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Gerald Choa Neuroscience Institute, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.; Division of Geriatrics, Department of Medicine and Therapeutics, Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China., Kwok TCY; Division of Geriatrics, Department of Medicine and Therapeutics, Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China., Mok KY; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom., Wong HY; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China., Zetterberg H; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.; United Kingdom Dementia Research Institute, University College London, London NW1 3BT, United Kingdom.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Göteborg 13 46, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal SE-43180, Sweden.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792-2420.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.; Centre for Brain Research, Indian Institute of Science, Bangalore 560012, India., Fu AKY; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Hong Kong University of Science and Technology Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong 518057, China.; Shenzhen Institutes of Advanced Technology-Hong Kong University of Science and Technology Joint Laboratory for Brain Science, Shenzhen, Guangdong 518055, China., Ip NY; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Hong Kong University of Science and Technology Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong 518057, China.; Shenzhen Institutes of Advanced Technology-Hong Kong University of Science and Technology Joint Laboratory for Brain Science, Shenzhen, Guangdong 518055, China.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 10; Vol. 123 (10), pp. e2536792123. Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification.
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  Data: <searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Zheng+W%22">Zheng W</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Xia+Z%22">Xia Z</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Wong+WW%22">Wong WW</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Cheng+LKW%22">Cheng LKW</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Ip+FC%22">Ip FC</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; 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Division of Geriatrics, Department of Medicine and Therapeutics, Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Kwok+TCY%22">Kwok TCY</searchLink>; Division of Geriatrics, Department of Medicine and Therapeutics, Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Mok+KY%22">Mok KY</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wong+HY%22">Wong HY</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.; United Kingdom Dementia Research Institute, University College London, London NW1 3BT, United Kingdom.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Göteborg 13 46, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal SE-43180, Sweden.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792-2420.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.; Centre for Brain Research, Indian Institute of Science, Bangalore 560012, India.<br /><searchLink fieldCode="AU" term="%22Fu+AKY%22">Fu AKY</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Hong Kong University of Science and Technology Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong 518057, China.; Shenzhen Institutes of Advanced Technology-Hong Kong University of Science and Technology Joint Laboratory for Brain Science, Shenzhen, Guangdong 518055, China.<br /><searchLink fieldCode="AU" term="%22Ip+NY%22">Ip NY</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Hong Kong University of Science and Technology Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong 518057, China.; Shenzhen Institutes of Advanced Technology-Hong Kong University of Science and Technology Joint Laboratory for Brain Science, Shenzhen, Guangdong 518055, China.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Mar 10; Vol. 123 (10), pp. e2536792123. <i>Date of Electronic Publication: </i>2026 Mar 02.
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