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Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.

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Title: Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.
Authors: Lim SY; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Lee J; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Chang E; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Kwon JS; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Jang CY; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Seo Y; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Park JJ; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Na SH; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Park H; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.)., Jang HM; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.)., Yun SC; Department of Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-C.Y.)., Kim SH; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.).
Source: Annals of internal medicine [Ann Intern Med] 2026 Apr; Vol. 179 (4), pp. 478-485. Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: American College of Physicians--American Society of Internal Medicine Country of Publication: United States NLM ID: 0372351 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-3704 (Electronic) Linking ISSN: 00034819 NLM ISO Abbreviation: Ann Intern Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Lim+SY%22">Lim SY</searchLink>; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.).<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.).<br /><searchLink fieldCode="AU" term="%22Chang+E%22">Chang E</searchLink>; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.).<br /><searchLink fieldCode="AU" term="%22Kwon+JS%22">Kwon JS</searchLink>; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.).<br /><searchLink fieldCode="AU" term="%22Jang+CY%22">Jang CY</searchLink>; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.).<br /><searchLink fieldCode="AU" term="%22Seo+Y%22">Seo Y</searchLink>; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.).<br /><searchLink fieldCode="AU" term="%22Park+JJ%22">Park JJ</searchLink>; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.).<br /><searchLink fieldCode="AU" term="%22Na+SH%22">Na SH</searchLink>; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.).<br /><searchLink fieldCode="AU" term="%22Park+H%22">Park H</searchLink>; Department of Infectious Diseases, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea (J.L., Y.S., J.J.P., S.H.N., H.P.).<br /><searchLink fieldCode="AU" term="%22Jang+HM%22">Jang HM</searchLink>; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.).<br /><searchLink fieldCode="AU" term="%22Yun+SC%22">Yun SC</searchLink>; Department of Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.-C.Y.).<br /><searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (S.Y.L., E.C., J.-S.K., C.Y.J., H.M.J., S.K.).
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  Data: <searchLink fieldCode="JN" term="%220372351%22">Annals of internal medicine</searchLink> [Ann Intern Med] 2026 Apr; Vol. 179 (4), pp. 478-485. <i>Date of Electronic Publication: </i>2026 Mar 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+College+of+Physicians--American+Society+of+Internal+Medicine%22">American College of Physicians--American Society of Internal Medicine </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372351 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1539-3704 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200034819%22">00034819 </searchLink><i>NLM ISO Abbreviation: </i>Ann Intern Med <i>Subsets: </i>MEDLINE
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        Value: 10.7326/ANNALS-25-04883
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      – TitleFull: Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 : A Randomized Clinical Trial.
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              Text: 2026 Apr
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